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Database: UniProt
Entry: A0A2K6VZ69_ONCVO
LinkDB: A0A2K6VZ69_ONCVO
Original site: A0A2K6VZ69_ONCVO 
ID   A0A2K6VZ69_ONCVO        Unreviewed;       477 AA.
AC   A0A2K6VZ69;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   16-OCT-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:OVOC3821.1};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC3821.1, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC3821.1, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC3821.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; CMVM020000122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC3821.1; OVOC3821.1; WBGene00240630.
DR   EnsemblMetazoa; OVOC3821.2; OVOC3821.2; WBGene00240630.
DR   EnsemblMetazoa; OVOC3821.3; OVOC3821.3; WBGene00240630.
DR   OMA; KVHTRHQ; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:EnsemblMetazoa.
DR   GO; GO:0043025; C:neuronal cell body; IEA:EnsemblMetazoa.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0046662; P:regulation of oviposition; IEA:EnsemblMetazoa.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    115    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    193    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    223       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      230    403       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     21       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   477 AA;  54614 MW;  117A614038441717 CRC64;
     MTLSVPTFPE VSKTRMPRKK RKMSLGTQPL LTINSLCIHS SSIADALSES FRTVAGMAGK
     QNSISLPRKV TKKLKKSRLI AKNGICNVYN TNVPKKDRQY LRDIFTTMID VKWRYMLVIF
     AIVFISSWTI FASFYYVISV LHGDIRNHLK RNILNHSVCI ENIDSFFSSF LFAVETHHTI
     GYGHRYITTE CPVAGAVICL QCICGLLIQS FMVGLVFAKM ARPKKRAETI IFSEKAVICL
     RDGHFCFLCR VGDMRNTHLV EAHVRLQFIT DRETAEGEIE PLHQYEMKVG PSTTDDDRIF
     LVWPTTLCHV IDRDSPLYEY DSNVLLSAQF EIIVLLEGIV ESTGMTAQAR TSYLPSEILW
     GHRFKKLVTY QRSNGSYQID YGIFHSTYEV KTPTCSASQF HERHLKNSEF FVHDEWIEHP
     LEDAQSTEST PTPLPSPYLT VNDCSINQFN FQNGNNYKMQ LVVSFILGKK YTTFLQI
//
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