ID   A0A2K6W0R0_ONCVO        Unreviewed;       371 AA.
AC   A0A2K6W0R0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC4199.2, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC4199.2}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ECSIT family.
CC       {ECO:0000256|ARBA:ARBA00007674}.
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DR   EMBL; CMVM020000128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2K6W0R0; -.
DR   STRING; 6282.A0A2K6W0R0; -.
DR   EnsemblMetazoa; OVOC4199.1; OVOC4199.1; WBGene00241008.
DR   EnsemblMetazoa; OVOC4199.2; OVOC4199.2; WBGene00241008.
DR   OMA; NMADFGV; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR046448; ECSIT_N.
DR   PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR   PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   Pfam; PF06239; ECSIT_N; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          238..360
FT                   /note="ECSIT C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01284"
SQ   SEQUENCE   371 AA;  43729 MW;  981B82B1CCD76D9C CRC64;
     MKVAMKLLGL RCGISLCCKP VQYLIYRFAS ESSQKIRKEL LPSEQSFSEV ANELRSKQTF
     LNVIDNFCKK QVHARGHVEF INTALKYMKE YGLQKDLDIY KSLLNVFPKG PMIPQNVFQQ
     RFLYYPQQQI CCVKLLDEME WFGVQPDKEI HDLVVNAFGE WNYATKKVKR MMYWMPKLKH
     SNIYLDRRKI EGKNLSAVDL GYLALKMISR DPGTRITLVR INDTKLDESD RWLLSSQSHL
     QKKLLQNLEN NTTLYVDGPN KVYLMDHCIE YVGLFSDPKS QYYEKHEEDD LDEDFENWKS
     EWGEEYERRP KYNIHEQQHE TILALSIFGK VCRETAVAWI SHLQESNLSL HNARVLFRTK
     QTSETLITEL S
//