ID   A0A2K6W2M4_ONCVO        Unreviewed;       496 AA.
AC   A0A2K6W2M4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Na_H_Exchanger domain-containing protein {ECO:0000313|EnsemblMetazoa:OVOC4415.2};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC4415.2, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC4415.2}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367}.
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DR   EMBL; CMVM020000131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2K6W2M4; -.
DR   STRING; 6282.A0A2K6W2M4; -.
DR   EnsemblMetazoa; OVOC4415.1; OVOC4415.1; WBGene00241224.
DR   EnsemblMetazoa; OVOC4415.2; OVOC4415.2; WBGene00241224.
DR   OMA; HINFKEQ; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR31102; -; 1.
DR   PANTHER; PTHR31102:SF1; NA_H_EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        101..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          56..431
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          469..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  54513 MW;  151F80DBC7D202BD CRC64;
     MVNAFAVLHR NIIHPIKYQG ENITWLEMLS NGAEVEAKAV LSQVDRHINS ALSVFILWLV
     ALSVGSLFTL CRLPNIIGVL LTGIAFKNIP FLNNSLYIDR IWSALFRKAA LTVILMRAGM
     GLDPEALRKT KVTVFRLGVI STLCEGGAIV LAAYFIFGVN IEMSILFGTI LSATGPAVTI
     PAILDLLKKG YGQGSGLPTA ILASCTIDNM TCIAAYTVAA SLIFTTVKLT YEIAMTFTTI
     AISVVVGVLG GRILWVFPHE GSHHRHFIRG VLLLSICLAL NFGTLAIGKP SCGVISTVLL
     NMVVTIKWKE ANVKFKEADA LALMWNFFAM QIMFGLIGFE FDIKNMKLQL VLKAVSIVMI
     GQIARILCSF LLSFGCDWQT EEHFFITFSF VSKATLQAAL APQVADKSRD SAMSHDAILL
     RIACVLAIFF LAPTGQLIFH TFGPTALKKE NIQKASTLSA ENPRKIFPLK PKARKDNQKQ
     RFESIEEHSE YHSHTN
//