ID   A0A2K6WH12_ONCVO        Unreviewed;       750 AA.
AC   A0A2K6WH12;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|EnsemblMetazoa:OVOC8180.1};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC8180.1, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC8180.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; CMVM020000247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2K6WH12; -.
DR   EnsemblMetazoa; OVOC8180.1; OVOC8180.1; WBGene00244989.
DR   EnsemblMetazoa; OVOC8180.2; OVOC8180.2; WBGene00244989.
DR   OMA; HIAYKFY; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IEA:EnsemblMetazoa.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF108; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        375..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        610..630
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        642..661
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        682..705
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        711..736
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          180..337
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   750 AA;  85220 MW;  B24F1955290C35D7 CRC64;
     MTHIYDRINR RIAITIATYP HHFLLATLLF SAFLSLSLFN LTLENDIRRS FSPPNSRAVR
     EEEIYKKFYN ITIVPQRAFI IVSAKDGGTM LRKNHIEEMY QINRLMTDAL HKAEYFDVPI
     CHPFCRLNEP VKLFWEEFNK NASNTDYDKD TIFAHPTSTI FGQELFLGSN LFDLESSGNA
     TKLMIVGFVF LICFVILVLW RKMELSLLPP IVFAIIFSPL LAAIVSFSVI SWLQLPIYSI
     MCITPFLILG IGVDDAFIMI QAWFRLSNIV SRKERLAQVF VEIGPSISIT SITNLIAFGI
     GYLTPTPQMS LFCLCTSFAC LFDYIFTFTL FAPILYLTSK PDDGYVMAKK VPKNEFGEQC
     LTSYSKLICS WKGRLIAIII LMVLYSLSSV GVMKMKSTFE PAKAFPSDSI SASSFRRLRN
     IFDEFFPLQV IINKPPNISD SAEYNEFYDM IRSLEAVPNS YGSNRTMVFL KTYEDYDRKI
     YSFLHMLGLT NQESFTPSYD NLPTFLDHIH NPPFIKMRVD EKGQHKLVAF IITATAQNMA
     EWSNRAMYVD ACRTVFRNYP RFNATVYNGD SAVLDLIMTV KKDLVGSITV TVLCMAIVCI
     FFIDSKIGVL IITFTISSIC FTLVGSLSWW GADMDPVTMV DVLIATGFSV DYTAHIAYKF
     YKLTGDREER IKESLREMCV PMLQAGISTV LCMLPLIFVP TYAILAFAKT VFLDVGLALL
     HGLFILPILL VTLCNYGQKE ANTDKTIIKS
//