ID A0A2K8KMK0_9GAMM Unreviewed; 796 AA.
AC A0A2K8KMK0;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=REIFOR_00192 {ECO:0000313|EMBL:ATX75369.1};
OS Reinekea forsetii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Saccharospirillaceae; Reinekea.
OX NCBI_TaxID=1336806 {ECO:0000313|EMBL:ATX75369.1, ECO:0000313|Proteomes:UP000229757};
RN [1] {ECO:0000313|EMBL:ATX75369.1, ECO:0000313|Proteomes:UP000229757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hel1_31_D35 {ECO:0000313|EMBL:ATX75369.1,
RC ECO:0000313|Proteomes:UP000229757};
RX PubMed=28000419;
RA Avci B., Hahnke R.L., Chafee M., Fischer T., Gruber-Vodicka H.,
RA Tegetmeyer H.E., Harder J., Fuchs B.M., Amann R.I., Teeling H.;
RT "Genomic and physiological analyses of 'Reinekea forsetii' reveal a
RT versatile opportunistic lifestyle during spring algae blooms.";
RL Environ. Microbiol. 19:1209-1221(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; CP011797; ATX75369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K8KMK0; -.
DR KEGG; rfo:REIFOR_00192; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000229757; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF49; LON PROTEASE HOMOLOG-RELATED; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122,
KW ECO:0000313|EMBL:ATX75369.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000229757};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 564..759
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 796 AA; 89375 MW; 71EA87F5F21359E4 CRC64;
MFPKVPSLAV TDLSAHIDLS HLNIESTSDL VGVSNFLGQP RAKKSLEFGI AMRGSGYNLY
VMGDAGTGRQ SLVSKYVREL AESQPAPSEW AYINNFDTPR EPEALELPAG RGEELKAQIS
QFVNDLLDTF PATFENPSYQ RKRTAIERDF NQKYDAAMKV VERFANDKEV AVVSDGGSVL
LLPIVDGQAL DDTEFAQLPE ERRSEFQDRI NDIEEYLNEQ VLELPTWRRK SSDAFRQLTL
ETVQQAIKPL LKELEVKNQS LLSVLRFFRS VKTNLPPLII DLFADEATAE SRTEQESRQM
LEHWLKPNLM MHHDINNGAP VVYEMLPTYQ NLFGRIEYST QQGMPITNYQ LIRPGSLLKA
NGGYLILDAE KLLQEPFAWD ALKLALKTKE LKMESPFIDA TLMPTVTLSP QSIKLNIKVI
LLGPRDIYYQ LQEWDPEFME LFRVPVDFDS FIPRTRDNID NLILRIKDYG EEKGFRPLTK
SALVRLIEFS LREAEHQHRL SAQVVKVFKV FAEADFICRH QDDRLIDAHH ITEALAAAEY
RNGRIADQML MEIEEGTILI DTTGERVGCV NGLTVMEIGE SHFGSPARIT ATVHVGGKGV
VDIEREVELG QSLHSKGVMI LSGFLGHEFG RTFPLTLSSH IAMEQSYGYI DGDSATVAEY
CSLMSAITRL PARQNLAITG SMNQLGEVQA IGGVNEKIEG FFKLCSLRGL TGEHGVIVPQ
DNVKHLMLQQ SVIDAVAAGQ FTIYAVKHVY EALHLLTDCE PGEADLKGDF PAESLNGKAQ
LALKTLYELY QETDEE
//
