ID A0A2K8NTT6_9MOLU Unreviewed; 161 AA.
AC A0A2K8NTT6;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=dfrA {ECO:0000313|EMBL:ATZ17177.1};
GN ORFNames=ELUMI_v1c04530 {ECO:0000313|EMBL:ATZ17177.1};
OS Williamsoniiplasma luminosum.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales;
OC Williamsoniiplasma.
OX NCBI_TaxID=214888 {ECO:0000313|EMBL:ATZ17177.1, ECO:0000313|Proteomes:UP000232063};
RN [1] {ECO:0000313|EMBL:ATZ17177.1, ECO:0000313|Proteomes:UP000232063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PIMN-1 {ECO:0000313|EMBL:ATZ17177.1,
RC ECO:0000313|Proteomes:UP000232063};
RA Lo W.-S., Gasparich G.E., Kuo C.-H.;
RT "Genome sequence of Entomoplasma luminosum PIMN-1 (ATCC 49195).";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR EMBL; CP024963; ATZ17177.1; -; Genomic_DNA.
DR RefSeq; WP_025734347.1; NZ_CP024963.1.
DR AlphaFoldDB; A0A2K8NTT6; -.
DR KEGG; elj:ELUMI_v1c04530; -.
DR OrthoDB; 9804315at2; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000232063; Chromosome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000232063}.
FT DOMAIN 1..161
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 161 AA; 18753 MW; 3B20D3195BAEF40A CRC64;
MIKLVYAQTQ DGVIGDDNKL PWSIPAEMKH FRQTTLHKNV LMGSKTFVSM NSRPLKNRLN
IVLTRNPKKF EGIEAENLIF TSDVDALIKK YQGPANDDLY VIGGNEIFTI FFDCADEIIR
SMILENYQGN VKISNYNFEN FKKINTIKEN EFEIEYFERK K
//
