ID   A0A2K8P6H4_STRLA        Unreviewed;       919 AA.
AC   A0A2K8P6H4;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=HTH-type transcriptional regulator {ECO:0000313|EMBL:ATZ22347.1};
GN   ORFNames=SLAV_02115 {ECO:0000313|EMBL:ATZ22347.1}, SLLC_00145
GN   {ECO:0000313|EMBL:QUQ52191.1};
OS   Streptomyces lavendulae subsp. lavendulae.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ22347.1, ECO:0000313|Proteomes:UP000231791};
RN   [1] {ECO:0000313|EMBL:ATZ22347.1, ECO:0000313|Proteomes:UP000231791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ22347.1,
RC   ECO:0000313|Proteomes:UP000231791};
RA   Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA   Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA   Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT   "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT   3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT   angucycline-type antibiotic auricin.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QUQ52191.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Del-LP {ECO:0000313|EMBL:QUQ52191.1};
RA   Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA   Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA   Kalinowski J., Kormanec J.;
RT   "The linear plasmid pSA3239 is essential for the replication of the
RT   Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL   Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP024985; ATZ22347.1; -; Genomic_DNA.
DR   EMBL; CP073778; QUQ52191.1; -; Genomic_DNA.
DR   RefSeq; WP_030226532.1; NZ_JOEW01000004.1.
DR   AlphaFoldDB; A0A2K8P6H4; -.
DR   GeneID; 82162520; -.
DR   KEGG; slx:SLAV_02115; -.
DR   OrthoDB; 7053960at2; -.
DR   Proteomes; UP000231791; Chromosome.
DR   Proteomes; UP000676025; Chromosome.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000231791}.
FT   DOMAIN          852..917
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   919 AA;  97856 MW;  6B7B5E17CACA17CE CRC64;
     MTDGSGAEQD GSLIGREDEL ERLGVFLAGP PRHGGSLVLA GEPGIGKTAL LTALTGRAEA
     TGTPVLRATG VQYRTQVGYG ALQQLLTSLP GTRSRAERMP ALAGVLGSEP DAAPGHDVVT
     EAVVALMADS SREVPALLVL DDAQWLDRPS AVVLGQVARR LPGTGTGLVC TVRPGEQGFF
     DHNGLPLHEL GPLGQAASDA LLRRRFPALA PRVRRRLIAE AEGNPLALLE LPAALTESQR
     TASRALPGRI PLTRRLQSTF GSRIEDLPPA TRHLLLVAAL EGSGNMLVVR RAVAGRCDLG
     HLAPAERTGL VRVDDATGRL AFRHSLVRSA VVELSTSDQR RNVHRALAEA WTEVPEQRAR
     HLAQAAEEPD EQIAALLEEA ADIGARRGDG PDAVSALVRA AELSPAPNAY ARRLAKAAYV
     GANLTGDVRH VPRLLDEARR AGPDADSPAA AVAAAMYLLN SYGDIDTAHR LLSGAIALQP
     EPYDLTDATL SEAMSTLFMV CVHAGRPELW SDFDAALSKC TSVPDTLELL RATFADPARA
     RPADWERLDC AIRALPGTPD PVRIVRIATA GAYADRLGAM EEPLRLTARG GLGGQNIFPA
     IQASFLWSSH AWFSGRWPEL RQVAGQGLRW CEELDYPLRS WTGKFVLACV HTVCGDYAAA
     GALADQMDQW AGSRRGHAVG CYAAHARALI ALSRGDFEGA HRQTARITPT GTFSPFAGHA
     VWAIMDQVEA AVRTGRRAQA AEHVRAAREA GLAAVSPRLA MVLLASAALA SERDAEAVRG
     LDAALAVEGA EGWPFDHARV HLYLGERLRR AKAPARARTH LSAAAEALGR LGAHPWTERA
     HQELRACGTP VPRPGASALT PQQRETARLA ATGLTNKQIA EKLGLSPRTV STHLHQLFPK
     LGIASRAALR DALERLDHP
//