ID A0A2K8P8P8_STRLA Unreviewed; 399 AA.
AC A0A2K8P8P8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase {ECO:0000313|EMBL:ATZ23114.1};
DE EC=2.3.1.174 {ECO:0000313|EMBL:ATZ23114.1};
GN Name=paaJ1 {ECO:0000313|EMBL:ATZ23114.1};
GN Synonyms=paaJ_1 {ECO:0000313|EMBL:QUQ52951.1};
GN ORFNames=SLAV_06045 {ECO:0000313|EMBL:ATZ23114.1}, SLLC_04070
GN {ECO:0000313|EMBL:QUQ52951.1};
OS Streptomyces lavendulae subsp. lavendulae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ23114.1, ECO:0000313|Proteomes:UP000231791};
RN [1] {ECO:0000313|EMBL:ATZ23114.1, ECO:0000313|Proteomes:UP000231791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ23114.1,
RC ECO:0000313|Proteomes:UP000231791};
RA Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT 3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT angucycline-type antibiotic auricin.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QUQ52951.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Del-LP {ECO:0000313|EMBL:QUQ52951.1};
RA Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA Kalinowski J., Kormanec J.;
RT "The linear plasmid pSA3239 is essential for the replication of the
RT Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP024985; ATZ23114.1; -; Genomic_DNA.
DR EMBL; CP073778; QUQ52951.1; -; Genomic_DNA.
DR RefSeq; WP_030229930.1; NZ_JOEW01000013.1.
DR AlphaFoldDB; A0A2K8P8P8; -.
DR GeneID; 82163265; -.
DR KEGG; slx:SLAV_06045; -.
DR OrthoDB; 1402717at2; -.
DR Proteomes; UP000231791; Chromosome.
DR Proteomes; UP000676025; Chromosome.
DR GO; GO:0033812; F:3-oxoadipyl-CoA thiolase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ATZ23114.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000231791};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ATZ23114.1}.
FT DOMAIN 9..268
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 277..399
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 95
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 356
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 386
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 399 AA; 40716 MW; 6F86190B4048E8B7 CRC64;
MSIRTVRDVY VVDAVRTPIG KFGGALAGIR PDDLAAHVVR ALVDRTPDLD PSRIDDVVFG
DANGAGEDNR DVARMAVLLA GLPVTVPGVT VNRLCGSGLE AVIQAARAIA VGDASVAIAG
GVESMTRAPW VVQKPERAFP AGHQQMWSTT LGWRMTNPAM PPEWTGSLGE GAELIAEKHG
ISREAQDLFA LESHRKAAAA WAGGLYDGEV VGYPGVDLLR DESIREGSTP ESLARLKPAF
RGDGSGTVTA GNASPLNDGA AALLLTDEAG LAATGREPLA RIGACAVTGI EPQLFGLGPV
DAVARALAKA DRRLADLSVL ELNEAFAAQA LGCLGAWPEL DPAAVNPRGG ALAIGHPLGA
SGARLAGSVA HQLAAAGSGT GMAALCIGVG QGIALVLER
//
