ID   A0A2K8PCE4_STRLA        Unreviewed;       400 AA.
AC   A0A2K8PCE4;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE            EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN   ORFNames=SLAV_12790 {ECO:0000313|EMBL:ATZ24417.1}, SLLC_10850
GN   {ECO:0000313|EMBL:QUQ54247.1};
OS   Streptomyces lavendulae subsp. lavendulae.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ24417.1, ECO:0000313|Proteomes:UP000231791};
RN   [1] {ECO:0000313|EMBL:ATZ24417.1, ECO:0000313|Proteomes:UP000231791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ24417.1,
RC   ECO:0000313|Proteomes:UP000231791};
RA   Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA   Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA   Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT   "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT   3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT   angucycline-type antibiotic auricin.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QUQ54247.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Del-LP {ECO:0000313|EMBL:QUQ54247.1};
RA   Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA   Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA   Kalinowski J., Kormanec J.;
RT   "The linear plasmid pSA3239 is essential for the replication of the
RT   Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL   Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP024985; ATZ24417.1; -; Genomic_DNA.
DR   EMBL; CP073778; QUQ54247.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K8PCE4; -.
DR   KEGG; slx:SLAV_12790; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000231791; Chromosome.
DR   Proteomes; UP000676025; Chromosome.
DR   GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ATZ24417.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000231791};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ATZ24417.1}.
FT   DOMAIN          10..267
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          276..396
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        93
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        354
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        384
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   400 AA;  41041 MW;  3E2F7A28E2BDC4B5 CRC64;
     MSGTNNTTSV IVAGARTPMG RLLGSLKSFS GADLGGFAIK SALERAGISG DQVQYVIMGQ
     VLQAGAGQIP ARQAAVKAGI PMNVPALTIN KVCLSGLDAI ALADQLIRAG EFDIVVAGGQ
     ESMTNAPHLL PKSREGFKYG AIEMLDAMAY DGLTDAFENI AMGESTEKHN TRLGIERAPQ
     DAFAAASHQR AAAAQKNGVF EAEITPVEIP QRKGDPVLFT ADEGIRAETT VESLGKLRPA
     FAKDGTITAG TSSQISDGAA AVVVMSKAKA EELGLEWIAE IGAHGNVAGP DNSLQSQPSN
     AILHALEKEG LEVSDLDLIE INEAFAAVAV QSMKDLGVTP EKVNVNGGAI ALGHPIGMSG
     ARVVLHLALE LKRRGGGVGA AALCGGGGQG DALVIRVPKA
//