ID A0A2K8PDK6_STRLA Unreviewed; 391 AA.
AC A0A2K8PDK6;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=pH-sensitive adenylate cyclase {ECO:0000313|EMBL:ATZ24834.1};
DE EC=4.6.1.1 {ECO:0000313|EMBL:ATZ24834.1};
GN ORFNames=SLAV_14900 {ECO:0000313|EMBL:ATZ24834.1}, SLLC_12965
GN {ECO:0000313|EMBL:QUQ54665.1};
OS Streptomyces lavendulae subsp. lavendulae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ24834.1, ECO:0000313|Proteomes:UP000231791};
RN [1] {ECO:0000313|EMBL:ATZ24834.1, ECO:0000313|Proteomes:UP000231791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ24834.1,
RC ECO:0000313|Proteomes:UP000231791};
RA Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT 3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT angucycline-type antibiotic auricin.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QUQ54665.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Del-LP {ECO:0000313|EMBL:QUQ54665.1};
RA Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA Kalinowski J., Kormanec J.;
RT "The linear plasmid pSA3239 is essential for the replication of the
RT Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP024985; ATZ24834.1; -; Genomic_DNA.
DR EMBL; CP073778; QUQ54665.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K8PDK6; -.
DR KEGG; slx:SLAV_14900; -.
DR OrthoDB; 310836at2; -.
DR Proteomes; UP000231791; Chromosome.
DR Proteomes; UP000676025; Chromosome.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR032026; Ad_Cy_reg.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR Pfam; PF16701; Ad_Cy_reg; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:ATZ24834.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000231791}.
FT DOMAIN 210..319
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 41937 MW; 20C09A67DFDF7B99 CRC64;
MTVDDPTSSA SGSGPGPGTG SGSGPGTPIG RDQHTPMHEV DHTAQPTADP LAIRLEQLIL
GAERRYTPFQ AARSAGVSME LASRFWRAMG FADIGQARAL TEADVLALRR LAGLVEAGLL
SEPMAVQVAR STGQTTARLA EWQIDSFLEG LTEPPEPGMT RTEVTYPLVE LLLPELEEFL
VYVWRRQLAA ATGRVVQVAD DEEMVDRRLA VGFADLVGFT RLTRRLEEEE LGELVEAFET
TAADLVAAHG GRLIKTLGDE VLYCADDAAT AAEIALRLIE TMEADPQMPE LRVGIAFGTV
TTRMGDVFGT TVNLASRLTS IAPKDAVLVD GAMAEELSRT GAAPKSEKGA EAEEGGGSYR
FALQPMWQRP VRGLGVVEPW SLTRRTPKIP G
//
