ID A0A2K8PL97_STRLA Unreviewed; 385 AA.
AC A0A2K8PL97;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Beta-ketoadipyl-CoA thiolase {ECO:0000313|EMBL:ATZ27248.1};
DE EC=2.3.1.174 {ECO:0000313|EMBL:ATZ27248.1};
DE SubName: Full=Steroid 3-ketoacyl-CoA thiolase {ECO:0000313|EMBL:QUQ57075.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:QUQ57075.1};
GN Name=pcaF2 {ECO:0000313|EMBL:ATZ27248.1};
GN Synonyms=fadA5_2 {ECO:0000313|EMBL:QUQ57075.1};
GN ORFNames=SLAV_27285 {ECO:0000313|EMBL:ATZ27248.1}, SLLC_25425
GN {ECO:0000313|EMBL:QUQ57075.1};
OS Streptomyces lavendulae subsp. lavendulae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ27248.1, ECO:0000313|Proteomes:UP000231791};
RN [1] {ECO:0000313|EMBL:ATZ27248.1, ECO:0000313|Proteomes:UP000231791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ27248.1,
RC ECO:0000313|Proteomes:UP000231791};
RA Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT 3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT angucycline-type antibiotic auricin.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QUQ57075.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Del-LP {ECO:0000313|EMBL:QUQ57075.1};
RA Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA Kalinowski J., Kormanec J.;
RT "The linear plasmid pSA3239 is essential for the replication of the
RT Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP024985; ATZ27248.1; -; Genomic_DNA.
DR EMBL; CP073778; QUQ57075.1; -; Genomic_DNA.
DR RefSeq; WP_030228255.1; NZ_JOEW01000008.1.
DR AlphaFoldDB; A0A2K8PL97; -.
DR GeneID; 82167403; -.
DR KEGG; slx:SLAV_27285; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000231791; Chromosome.
DR Proteomes; UP000676025; Chromosome.
DR GO; GO:0033812; F:3-oxoadipyl-CoA thiolase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ATZ27248.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000231791};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ATZ27248.1}.
FT DOMAIN 5..253
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 263..384
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 341
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 371
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 385 AA; 40409 MW; 6073EA996938F38C CRC64;
MPEAYIVDAV RTPVGRRGGG LSAVHPADLG AHVLKALVER TGIDPAAVED VVFGCLDTVG
PQAGDIARTA WLAAGLPEEV PGVTVDRQCG SSQQAVHFAA QGVLSGTQDL VVAGGTQNMS
MIPIAFASRQ AAEPLGLTEG PYAGSAGWRA RYGDAPVNQF HGAQLIAEKW GISRRDMEEF
ALRSHRRALR AVDEGRFERE TVAYGDVRVD EGPRRDTSLE KMAGLKPVVE GGTITAAVSS
QVSDGAAAML IASGRAVAEH GLTPRARVHH LSVRGEDPIR MLSAPIPATA HALKKTGLTL
SDIDLVEINE AFAPVVLAWL KETGADPDRV NVNGGAIALG HPLGATGVKL MTTLLHELER
TGGRYGLQTM CEGGGQANVT IIERL
//
