ID A0A2K8PN17_STRLA Unreviewed; 501 AA.
AC A0A2K8PN17;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Alcohol dehydrogenase [acceptor] {ECO:0000313|EMBL:ATZ28152.1};
DE EC=1.1.99.- {ECO:0000313|EMBL:ATZ28152.1};
GN Name=alkJ {ECO:0000313|EMBL:ATZ28152.1};
GN ORFNames=SLAV_31900 {ECO:0000313|EMBL:ATZ28152.1}, SLLC_30070
GN {ECO:0000313|EMBL:QUQ57980.1};
OS Streptomyces lavendulae subsp. lavendulae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=58340 {ECO:0000313|EMBL:ATZ28152.1, ECO:0000313|Proteomes:UP000231791};
RN [1] {ECO:0000313|EMBL:ATZ28152.1, ECO:0000313|Proteomes:UP000231791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 3239 {ECO:0000313|EMBL:ATZ28152.1,
RC ECO:0000313|Proteomes:UP000231791};
RA Busche T., Novakova R., Al'Dilaimi A., Homerova D., Feckova L.,
RA Rezuchova B., Mingyar E., Csolleiova D., Bekeova C., Winkler A.,
RA Sevcikova B., Kalinowski J., Kormanec J., Ruckert C.;
RT "Complete genome sequence of Streptomyces lavendulae subsp. lavendulae CCM
RT 3239 (formerly 'Streptomyces aureofaciens CCM 3239'), the producer of the
RT angucycline-type antibiotic auricin.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QUQ57980.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Del-LP {ECO:0000313|EMBL:QUQ57980.1};
RA Novakova R., Ruckert C., Knirschova R., Feckova L., Busche T.,
RA Csolleiova D., Homerova D., Rezuchova B., Javorova R., Sevcikova B.,
RA Kalinowski J., Kormanec J.;
RT "The linear plasmid pSA3239 is essential for the replication of the
RT Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.";
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CP024985; ATZ28152.1; -; Genomic_DNA.
DR EMBL; CP073778; QUQ57980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K8PN17; -.
DR KEGG; slx:SLAV_31900; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000231791; Chromosome.
DR Proteomes; UP000676025; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000313|EMBL:ATZ28152.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000231791}.
FT DOMAIN 6..292
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 360..496
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT BINDING 217
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 439
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 501 AA; 52065 MW; E42D778650A76FF3 CRC64;
MGRRPYDYVV VGAGTAGCVI ASRLTERPRV RVLLLEAGAR DATEAMASPW GFLGFDPSTL
WLGSSTVQAG TGRAADVLRG KALGGSSSIN GLYHLRGHRS GYDEWPGLGA PGWGFDDLLP
HFRRSESTRG RDASVRGTEG PVVVAPVPEP HPLAMAGVDA AVQAGFTRAD DIGGGLETGF
GWSDMNLPGG ARQSAADAYI RPFLGRPDLD VVTDATVRRL RITAGRCTGV EYTVGGRHLS
VESAEVILTA GAIGSAHLLM LSGIGPARHL GEHGIGVVAD LPGVGSHLQD HPMAAVVYEA
GRPVPFVPAN PPAEMMGLLY SDPAAPRPDL QVYVVAAPLP SAWGQPPANG YSIAFSAMAP
YSSGTVRLAD ADPAGAPVVD PGYLSDDRDL EVMRKGLAVA RRIGEADAFA DWRGQEAVPG
PGTSGASVEE FLRKATGPYF HFTGTCRMGT DADAVVDPAN LRVHGLAGLR VADASVMPSI
PSANTNATVY AIAERAAELL G
//
