ID   A0A2K8XC94_9FLAO        Unreviewed;       815 AA.
AC   A0A2K8XC94;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   SubName: Full=Zinc-dependent metalloprotease {ECO:0000313|EMBL:AUC80508.1};
GN   ORFNames=CW736_06690 {ECO:0000313|EMBL:AUC80508.1};
OS   Nonlabens sp. MB-3u-79.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Nonlabens.
OX   NCBI_TaxID=2058134 {ECO:0000313|EMBL:AUC80508.1, ECO:0000313|Proteomes:UP000232401};
RN   [1] {ECO:0000313|EMBL:AUC80508.1, ECO:0000313|Proteomes:UP000232401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MB-3u-79 {ECO:0000313|EMBL:AUC80508.1,
RC   ECO:0000313|Proteomes:UP000232401};
RA   Collins E., Ducluzeau A.-L.;
RT   "Pharmacopeia of the Arctic Ocean.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP025116; AUC80508.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K8XC94; -.
DR   KEGG; nob:CW736_06690; -.
DR   OrthoDB; 9776599at2; -.
DR   Proteomes; UP000232401; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04276; ZnMc_MMP_like_2; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   InterPro; IPR033413; DUF5117.
DR   InterPro; IPR033428; DUF5118.
DR   InterPro; IPR032534; EcxA_zinc-bd.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR034032; Zn_MMP-like_bac.
DR   PANTHER; PTHR38478; PEPTIDASE M1A AND M12B; 1.
DR   PANTHER; PTHR38478:SF1; ZINC DEPENDENT METALLOPROTEASE DOMAIN LIPOPROTEIN; 1.
DR   Pfam; PF16313; DUF4953; 1.
DR   Pfam; PF17148; DUF5117; 1.
DR   Pfam; PF17162; DUF5118; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AUC80508.1};
KW   Metalloprotease {ECO:0000313|EMBL:AUC80508.1};
KW   Protease {ECO:0000313|EMBL:AUC80508.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000232401}.
FT   DOMAIN          39..87
FT                   /note="DUF5118"
FT                   /evidence="ECO:0000259|Pfam:PF17162"
FT   DOMAIN          95..284
FT                   /note="DUF5117"
FT                   /evidence="ECO:0000259|Pfam:PF17148"
FT   DOMAIN          419..725
FT                   /note="EcxA zinc-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16313"
SQ   SEQUENCE   815 AA;  92798 MW;  8F8FEB3D3DB9B3E1 CRC64;
     MVLLLAVSVT TSCSIFQGKK KAPADKTASD KKPKKGDIQP YSKVITKEAK SDEGLFTVHQ
     VEDKWFYEIP DSLFNREMLM VTRIAKTAAG LGFGGGKQNT QTLRWQKNNK DVLLRVVSHE
     VVAADSLPVS IAVENSNFEP ILYSFPVKAI KKDSLTNNTV IDVTDFFTKD VKAIGFPQRA
     RTRLKISRLD DSRSYIDTLR SYPQNIESRH VKTYFSSSPP SNGSVQSISL EMSNSMILLP
     KVPMKRRYFD QRVGWFARGQ QDYGLNDQKT KTVTYLDRWR LEVKDEDLAK FNAGELVVPK
     KQIVYYIDPA TPVQWRKYIK LGIEDWQVAF EAAGFKEAII AKDAPTKEEN PEWSPEDVRY
     SVVRYLASPI PNANGPHVSD PRSGEILESD INWYHNVMTL LHNWFFIQTA AINPDARMNN
     FDDEVMGRLI RFVSSHEVGH TLGLPHNMGS SIAYPVEKLR DPAFTKEFGT APSIMDYARF
     NYVAQPEDGD VALMPEVGPY DKYSIAWGYK PILDKSAKEE KETLDAWILE KAGDPVYRFG
     RQQFGVIDYT SQTEDLGDDS MLASEYGIKN LKRIVPNLGK WTGEEGENFD ELENMYGQLV
     GQFNRYMGHV SGNIGGIKET YKAYGQEGAV YEHAPKDKQE RAMTFLNTQL FDTPEWLIDQ
     NIFNRIEPAG GIERIRSIQV RTLNNVLDFG RMARLMENEE VNGNSAYGLL DMMTELRKGL
     FKELPRGQTI DRYRRNLQRA YVERLAFIMT NDAPSGRFGG TSIDVAQSDI RPIVRAELET
     LKRDASRATN RTSDRLSKIH LRDLEERIDM ILDPK
//