ID   A0A2K8XM80_9FLAO        Unreviewed;       740 AA.
AC   A0A2K8XM80;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=RelA/SpoT family protein {ECO:0000313|EMBL:AUC84059.1};
GN   ORFNames=CW731_01580 {ECO:0000313|EMBL:AUC84059.1};
OS   Polaribacter sp. ALD11.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae.
OX   NCBI_TaxID=2058137 {ECO:0000313|EMBL:AUC84059.1, ECO:0000313|Proteomes:UP000232878};
RN   [1] {ECO:0000313|EMBL:AUC84059.1, ECO:0000313|Proteomes:UP000232878}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ALD11 {ECO:0000313|EMBL:AUC84059.1,
RC   ECO:0000313|Proteomes:UP000232878};
RA   Collins E., Ducluzeau A.-L.;
RT   "Pharmacopeia of the Arctic Ocean.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP025119; AUC84059.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K8XM80; -.
DR   KEGG; poa:CW731_01580; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000232878; Chromosome.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000232878}.
FT   DOMAIN          59..159
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          403..464
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
SQ   SEQUENCE   740 AA;  84333 MW;  E3621DF6A081CC91 CRC64;
     MQYTATIEEE NKEIASRYKH LLKGTYEILS VEDKKLIRKA FEIAVDAHSE QRRKTGEPYI
     FHPIAVAKIV ATEIGLGATS IAAALLHDVV EDTDYTIDDM EQLFGETIAR IVNGLTKISR
     LNKEQDVSIQ AENFRKMLLT LNDDVRVILI KIADRLHNMQ TMDAMPAYKQ VKIASETLYI
     YAPLAHRLGL YNIKTELEDL GLKYTEPEVF NDIVTKIKES KEDQKKYLET FAETLKKGLD
     KENFTYDIKG RFKSIYSIRR KMRKQNVTFE EVYDKYAIRI IYTPTSGDDK FDAWKIYTIV
     TDYFKPNPTR LRDWISQPKS TGYEALHITV IGPSAQWVEV QIRSSRMNEI AEKGYAAHFK
     YKQGNSNESG LETWLNKLKE SLENQSLNAV DFVEEFKLNL YAKEIYVFTP KGDLKSLPKD
     ASALDFAFSI HTDVGLKCRG AKVNGKLVPL SHTLKSGDQI EVITTSTNKP NSRWLDFVIT
     ARAKTKIRAA LKDEEKKIAE EGKAILTRKL RHLKIPFNEK TINELVSFFK IRTSFDLFYR
     IGSGAIDNTN LKTYVAQRNS TILNFFKTKL RRTPSGNKEI VESDEVTSKY DALVFGKEEE
     KLDYKLSKCC NPIPGDSVFG FLTINEGIKV HKKNCPNAIS LQSNYAYRIM LAKWIDSTKQ
     DFKVFLLISG VDNRGIINDL TKIISSNMGV FINSINIAGN EGVFEGKISL SVKNSSQLNK
     LIKSIQKVEG VKKVDRVNSL
//