ID   A0A2K9BMD8_9MOLU        Unreviewed;       826 AA.
AC   A0A2K9BMD8;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=CXP39_00050 {ECO:0000313|EMBL:AUF83203.1};
OS   Mesoplasma syrphidae.
OC   Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales;
OC   Entomoplasmataceae; Mesoplasma.
OX   NCBI_TaxID=225999 {ECO:0000313|EMBL:AUF83203.1, ECO:0000313|Proteomes:UP000233419};
RN   [1] {ECO:0000313|EMBL:AUF83203.1, ECO:0000313|Proteomes:UP000233419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJS {ECO:0000313|EMBL:AUF83203.1,
RC   ECO:0000313|Proteomes:UP000233419};
RA   Knight T.F., Citino T., Rubinstein R., Neuschaefer Z.;
RT   "Mesoplasma syrphidae YJS, Complete Genome.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; CP025257; AUF83203.1; -; Genomic_DNA.
DR   RefSeq; WP_027048309.1; NZ_CP025257.1.
DR   AlphaFoldDB; A0A2K9BMD8; -.
DR   KEGG; msyr:CXP39_00050; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000233419; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   NCBIfam; TIGR01063; gyrA; 1.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233419};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          17..470
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   826 AA;  92520 MW;  20C927CA981B0FCA CRC64;
     MSNENKIEHN HGTIKPMDIS AEVRKDFLEY AMSVIVSRAL PDLKDGLKPV HRRIIYAMND
     LGITAEKPHK KSARIVGEVI GKYHPHGDSA VYESMVRMAQ DFSYRYPLVD GHGNFGSIDG
     DGAAAMRYTE ARLSKVSNFI IKDIDMDTVP FVDNYDASER EPAYLTGYFP NLLANGAMGI
     AVGMATSIPP HNLREVVSAI SAYIDDNEIT IDEILNNHIK GPDFPTGALM TNGARMREGY
     KTGRGGVIIR AKIDIEENDR HSRLIITEIP YQTNKAKVIE RIAELVKDKA IDGISDLRDE
     SNYEGIRIVV DLKRDANPDV VLSKLYKYTN LQSSYSINLL SLHNNIPLLL DLKTIIKNYV
     EFQIAIIIKR SIYEKNKLDK RHHILGALHK ALSNIDQVVA IIRNAKTSDQ AKEQLTATFG
     FDDEQNKAIL DMRLQRLVGL EREKIAEEMA AIQERITYLN FLIADTAEQN RVLKEQLSDI
     ALKFGDNRRT ETISESVMNI QDEELIPDEK TMILLSEQGY IRRVDAEEFR IQKRGGRGVS
     VNSANDDPIS IATMGKMRDW ILFFTNSGKV FRTKAYNIRQ YSRTARGLPI VNFLNGLTNE
     DKITAILPLR NVKEKFKYLT FITQNGMIKR TDISLFDSIN QNGKIAITLK ESDQLITVMP
     TTGEDSVFIA NKSGKVIRIN ENIVRPLSRT ASGVKGIKLD TDDIVVGAVS SFGIENITTI
     SSRGNFKKTA LLEYRISGRN GKGIKVMNLN EKTGDFKAII AARETDLILI ISSDGNLIKS
     KVADIPTLGR SAAGVRGIRL SGVNEIKAVT LQYRKNGEEN QEFEED
//