ID A0A2K9E920_9FIRM Unreviewed; 161 AA.
AC A0A2K9E920;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN Name=sirC {ECO:0000313|EMBL:AUG56494.1};
GN ORFNames=B9R14_07295 {ECO:0000313|EMBL:PQQ66571.1}, HVS_02695
GN {ECO:0000313|EMBL:AUG56494.1};
OS Acetivibrio saccincola.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Acetivibrio.
OX NCBI_TaxID=1677857 {ECO:0000313|EMBL:AUG56494.1, ECO:0000313|Proteomes:UP000233534};
RN [1] {ECO:0000313|EMBL:AUG56494.1, ECO:0000313|Proteomes:UP000233534}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GGR1 {ECO:0000313|EMBL:AUG56494.1}, and SR1
RC {ECO:0000313|Proteomes:UP000233534};
RA Pechtl A., Ruckert C., Koeck D.E., Maus I., Winkler A., Kalinowski J.,
RA Puhler A., Schwarz W.W., Zverlov V.V., Schluter A., Liebl W.;
RT "Complete genome sequence of Herbivorax saccincola GGR1, a novel
RT Cellulosome-producing hydrolytic bacterium in a thermophilic biogas plant,
RT established by Illumina and Nanopore MinION sequencing.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PQQ66571.1, ECO:0000313|Proteomes:UP000239720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A7 {ECO:0000313|EMBL:PQQ66571.1,
RC ECO:0000313|Proteomes:UP000239720};
RX PubMed=29482868; DOI=10.1016/j.syapm.2018.01.010;
RA Aikawa S., Baramee S., Sermsathanaswadi J., Thianheng P., Tachaapaikoon C.,
RA Shikata A., Waeonukul R., Pason P., Ratanakhanokchai K., Kosugi A.;
RT "Characterization and high-quality draft genome sequence of Herbivorax
RT saccincola A7, an anaerobic, alkaliphilic, thermophilic, cellulolytic, and
RT xylanolytic bacterium.";
RL Syst. Appl. Microbiol. 41:261-269(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
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DR EMBL; CP025197; AUG56494.1; -; Genomic_DNA.
DR EMBL; NEMB01000003; PQQ66571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9E920; -.
DR KEGG; hsc:HVS_02695; -.
DR OrthoDB; 9773765at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000233534; Chromosome.
DR Proteomes; UP000239720; Unassembled WGS sequence.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AUG56494.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000233534}.
SQ SEQUENCE 161 AA; 18212 MW; 92F6EDAE5697A6CB CRC64;
MKNKREYSHF PLFVNLKDKK IIVVGGGKVA LRRIKVIIKF GAKVTVIAPE VKKELELIYH
EGKINIIKRE YKKGDIKGAY MVIAATDKKS VNEAVAKEAR ELKILVNTAD NKENSDFFFP
AIFSDEDIIG GMISNNGNNH SMVKEKAAKI RDFFKKGRIT E
//
