ID A0A2K9F2X7_9RHOB Unreviewed; 878 AA.
AC A0A2K9F2X7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=CUV01_08910 {ECO:0000313|EMBL:AUH33491.1};
OS Paracoccus tegillarcae.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=1529068 {ECO:0000313|EMBL:AUH33491.1, ECO:0000313|Proteomes:UP000233742};
RN [1] {ECO:0000313|EMBL:AUH33491.1, ECO:0000313|Proteomes:UP000233742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BM15 {ECO:0000313|EMBL:AUH33491.1,
RC ECO:0000313|Proteomes:UP000233742};
RA Hurst M.R.H.;
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP025408; AUH33491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9F2X7; -.
DR KEGG; paro:CUV01_08910; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000233742; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000233742}.
FT DOMAIN 700..716
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 878 AA; 94970 MW; E249FC48A7EB10A2 CRC64;
MSDQPTPMMA QYLAIREANP GALLFYRMGD FYEMFFDDAV AAAAALDIAL TKRGTHEGQP
IPMCGVPFHA AESYLLTLIR KGFRVAIAEQ MEDPAEAKKR GSKSVVARDV VRLVTPGTLT
EEALLEARRH NFLAAFAQVR DQAALAWVDI STGAFQVMDC PMSRLAPELA RLAPRELLAV
DGSGLDDLAG DAGAALTGLP PGAFDSASGT RRLCALFKVE TLDGFGAFSR AELSAMGAIV
DYLELTQKGN LPLLRPPVRE RASGAMQIDA ATRRNLELTQ ALSGGREGSL LTAIDRTVTA
AGARLLERRI SAPSRDLALI HARQEAVAQL VEDARLSADL RAALALAPDM DRALSRLALD
RGGPRDLAAI RAGLSQGAEI ATRFPADAAQ VLRQAVRDLT GHDALIQLLD DALVAEPPLL
TRDGGFVAPD YDEDLDETRR LRDEGRGVIA RMQSDYAALA GVQSLKIKHN NVLGYFIETT
TTHAEKMMAP PLSETFIHRQ TTANQIRFTT VELSELETRI LNARDRALQI ERAVFERLRE
AVLERAPQIG QAARALAEID LAAGFADIAS GESWTRPRVD DSRAFVIEGG RHPVVERALK
RKAEAFVAND CDLTSGDTPA IWLLTGPNMA GKSTFLRQNA LIAVLAQAGA FVPARRAHIG
MVSQLFSRVG AADDLARGRS TFMVEMVETA AILNQADDHA LVILDEIGRG TATWDGLSIA
WAVMEHLHAA NRCRALFATH YHEMTALTAK LDGVENATVT VREWEGEVIF LHEVRKGAAD
RSYGVQVARL AGLPASVVER AREVLDALES GEREGATRPA ALIDDLPLFR AIPPAPAAAT
PKDNPVDLRM KDIHPDTLSP REALDLIYEL KSLTGDTA
//
