ID   A0A2K9LN67_9GAMM        Unreviewed;       340 AA.
AC   A0A2K9LN67;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=NAD(P)H steroid dehydrogenase {ECO:0000313|EMBL:AUM12234.1};
GN   ORFNames=Kalk_07335 {ECO:0000313|EMBL:AUM12234.1};
OS   Ketobacter alkanivorans.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Ketobacteraceae; Ketobacter.
OX   NCBI_TaxID=1917421 {ECO:0000313|EMBL:AUM12234.1, ECO:0000313|Proteomes:UP000235116};
RN   [1] {ECO:0000313|Proteomes:UP000235116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GI5 {ECO:0000313|Proteomes:UP000235116};
RA   Kim S.-J., Rhee S.-K.;
RT   "Direct submision.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; CP022684; AUM12234.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K9LN67; -.
DR   KEGG; kak:Kalk_07335; -.
DR   OrthoDB; 9801056at2; -.
DR   Proteomes; UP000235116; Chromosome.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000235116}.
FT   DOMAIN          7..256
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   340 AA;  37156 MW;  F994B94A096DA5CE CRC64;
     MEKRNILVTG GCGFIGSNLV SGFVDAGHKV TVLDFGGKPF RDDVTFLDVN VCDKQAVIDA
     CKGMDTVVHN ASLVHTKHNR ESVIWEVNHQ GTLHVMEACR VHSIPRLVYI SSASAVYEGE
     DIINGDETLP YSNISQAPYA DSKIQAEKDV LAFSGSGVTQ CCAIRPHVVF GVGDNRFMPA
     ILQKAQEGKL KRAIGNRDKL SDFTYVSNLV DAVVMAENAL VPRSPVCGQA YFITNGEPMP
     FFDFVEKVLV ELGYPPIKGK VPYWLAYSVA AIAEGLDTLK GGTLNAENGL TRFSVRYMVT
     HHYFSINKAQ RDFGWQPKVS LDEGIAITVA ALKEKPVRAA
//