ID A0A2K9LPU3_9GAMM Unreviewed; 940 AA.
AC A0A2K9LPU3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kalk_17780 {ECO:0000313|EMBL:AUM14161.1};
OS Ketobacter alkanivorans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Ketobacteraceae; Ketobacter.
OX NCBI_TaxID=1917421 {ECO:0000313|EMBL:AUM14161.1, ECO:0000313|Proteomes:UP000235116};
RN [1] {ECO:0000313|Proteomes:UP000235116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GI5 {ECO:0000313|Proteomes:UP000235116};
RA Kim S.-J., Rhee S.-K.;
RT "Direct submision.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP022684; AUM14161.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9LPU3; -.
DR KEGG; kak:Kalk_17780; -.
DR Proteomes; UP000235116; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR015168; SsuA/THI5.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF09084; NMT1; 1.
DR Pfam; PF00989; PAS; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235116};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..940
FT /note="Diguanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014888357"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 370..412
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 442..504
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 536..669
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 678..932
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 940 AA; 105114 MW; 4C51E8856D817C7E CRC64;
MLRHIPFILL FFFIAFSASA EELKPLTVQL KWQHQFQFAG FYAAVEKGFY RKAGFEVTLK
QAAVGVNPIE VVLSGKADYG VANSELLLYH LKGSPVTALA VLIQHSPLVL VSLENSGIYS
PQDLIGKRVM FPAGPYGANT LGLLAREGVE ASQVKQVPMS FNVDDLINGQ VDAMVGYATD
LPYQLNEKGV AFNLIQPRSY GIDFYGDTLF TSRDRVGNKS EEVRLFRNAT LAGWRYALEH
PQEVIGFLQT RFRSSKDLEA LQFEATAMRK LMAPTLVDLG HMNPGRWQHI GETFAALGMG
PKKIDLDGFL YDPNRTVFNE RMRQLIWWMV IAAALVGLLL LLLVALNWRL NRKVSAHALE
LAERKHREIS LRLLSKAVEN SHSGVLIIDS SEKVVYANPA FCEQCGLDAP ELQSMNLSDV
RRYLALPEID SRCWEGSAEL AVPVEVKGRF ADGSERWVQV AVSPILEYPD QGVELYREPA
PVSHYVFSCE DITPQKKSQE QMEKLAFYDQ LTGLESRLLF KLRLENALAR SARDNKMTAL
MFIDLDLFKK INDHYGHDVG DEVLKAVATR IRQTVRSNDT VARISGDEFT VIVSDIVDHT
VVRRVAEDIL NSLTKAINVA GIEHVVSVSI GIAITPSDAN DVETLTKHAD VAMYQAKKSG
RNGVQFFSHS MNEWVREKKQ LEQDMREALS ERQFKLVYQP VVELTTGKLV GLEVLLRWQH
PVRGSISPEY FIPLAEESGL ILPLGKWLAH ELIAAMQRIS SVGVTGLMMS INMSPKQVRD
DALLRDVSQI LQRQGVDDFR LLLELTERAL RDDGRNDGVN LRRLTELGFK LVIDEFGEGG
VSVRMLSELP AEYIKISRQF VQECAYNVAS QQAICATLAL ARCLGIQAIA VGVESLDQVR
FLREQGCALG QGHLFSPASE LEELLDRFSP DNVVMFTSAT
//
