ID A0A2K9MBU5_9RHOB Unreviewed; 417 AA.
AC A0A2K9MBU5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN ORFNames=CYR75_00470 {ECO:0000313|EMBL:AUM72982.1};
OS Paracoccus jeotgali.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=2065379 {ECO:0000313|EMBL:AUM72982.1, ECO:0000313|Proteomes:UP000234882};
RN [1] {ECO:0000313|Proteomes:UP000234882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBA4604 {ECO:0000313|Proteomes:UP000234882};
RA Roh S.W., Kim J.Y., Kim J.S.;
RT "Genomic analysis of Paracoccus sp. CBA4604.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743,
CC ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; CP025583; AUM72982.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9MBU5; -.
DR REBASE; 228750; M.Psp4604ORF470P.
DR KEGG; paru:CYR75_00470; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000234882; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd00315; Cyt_C5_DNA_methylase; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 3.90.120.30; -; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF13560; HTH_31; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000234882};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 6..50
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT ACT_SITE 135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 417 AA; 46212 MW; 05B8A160629954E9 CRC64;
MEQFSALRQA AGLNMQQAAA LTGCAMSTAY RWENGEIEPR PEALDALRRA AGGAGGPVAP
AFKFIDLFAG IGGLRRGFDA IGGHCVFTSE WDRFAQQTYR ANYHDGPDHV FKGDITKVEM
HEIPEHDVLL AGFPCQPFSI AGVSKKNSLG RQHGFHCDTQ GTLFFDVARI IESHRPKVFL
LENVKNLLSH DKGRTFAVIG RTLEEELGYR ISSRVIDARC FVPQHRERIF IVGVRRDLDL
KIDLSKLELP SGAAGPRLGT ILHNEDGSEL PSNQSFLDQE GRVSDRYTLS DKLWKYLQDY
AEKHRQKGNG FGFGLTGRGD VARTLSARYH KDGSEILVDR GPGLNPRRLT PRECARLMGF
DRPGQSEFLM PVSDTQAYRQ FGNSVVVPVV EAMARHMQPV IKSAVAHMRA APAVAAE
//
