ID A0A2K9MHU5_9RHOB Unreviewed; 316 AA.
AC A0A2K9MHU5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Metallo-beta-lactamase type 2 {ECO:0000256|ARBA:ARBA00017223};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=B2 metallo-beta-lactamase {ECO:0000256|ARBA:ARBA00030107};
DE AltName: Full=Metallo-beta-lactamase type II {ECO:0000256|ARBA:ARBA00033087};
GN ORFNames=CYR75_13685 {ECO:0000313|EMBL:AUM75208.1};
OS Paracoccus jeotgali.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=2065379 {ECO:0000313|EMBL:AUM75208.1, ECO:0000313|Proteomes:UP000234882};
RN [1] {ECO:0000313|Proteomes:UP000234882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBA4604 {ECO:0000313|Proteomes:UP000234882};
RA Roh S.W., Kim J.Y., Kim J.S.;
RT "Genomic analysis of Paracoccus sp. CBA4604.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Class-B
CC beta-lactamase family. {ECO:0000256|ARBA:ARBA00005250}.
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DR EMBL; CP025583; AUM75208.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9MHU5; -.
DR KEGG; paru:CYR75_13685; -.
DR OrthoDB; 420651at2; -.
DR Proteomes; UP000234882; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd16282; metallo-hydrolase-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR42951:SF20; BETA LACTAMASE; 1.
DR PANTHER; PTHR42951; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AUM75208.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234882};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 33..219
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 316 AA; 35379 MW; 6B9DBB1E2752E028 CRC64;
MSKQFASAGD MEEKQISFSE IGEGLWAFTA EGDPNTGVII GDDSVMIVEA QATPRLARKV
IEKVREVTDK PISHLVMTHY HAVRVLGASA YEAPTVIMGD AARAMVVERG QEDWDSEFQR
FPRLFQGHEE IPGLTWPTTT FNDRMTVYLG NRRIDLMHLG RAHTAGDIVV HVPDENVMFT
GDIVEYHSAC YCGDGHLQDW PWTLEAIREY DLAAIAPGRG DALVGAEMVN AALDNTADFV
RSTYQPAARV AARNGTLREA WDAVRAECDP KFADYAIYEH CLPFNVARAY DEARGIDTPR
IWTAERDREM WELLQG
//
