ID A0A2K9MIR3_9RHOB Unreviewed; 610 AA.
AC A0A2K9MIR3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=CYR75_12120 {ECO:0000313|EMBL:AUM74926.1};
OS Paracoccus jeotgali.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=2065379 {ECO:0000313|EMBL:AUM74926.1, ECO:0000313|Proteomes:UP000234882};
RN [1] {ECO:0000313|Proteomes:UP000234882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBA4604 {ECO:0000313|Proteomes:UP000234882};
RA Roh S.W., Kim J.Y., Kim J.S.;
RT "Genomic analysis of Paracoccus sp. CBA4604.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP025583; AUM74926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9MIR3; -.
DR KEGG; paru:CYR75_12120; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000234882; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:AUM74926.1};
KW Hydrolase {ECO:0000313|EMBL:AUM74926.1};
KW Nuclease {ECO:0000313|EMBL:AUM74926.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234882}.
FT DOMAIN 220..338
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 423..566
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 610 AA; 65549 MW; 2BC2BBF7ECB39B59 CRC64;
MNTHSRHISR VIRQLDESTA NRIAAGEVVE RPASAVKELV ENALDAGAGR IDVTISDGGK
ALIRVVDDGC GMTPQDLPLA LARHATSKID GSDLLAIDSF GFRGEALPSL GAVGRLTITS
RAEGAEGAEI GVTAGRMQPL RPAAGNRGTA VELRDLFFAT PARLKFLRST RAETQAVVEV
MRRLAMAEPG VGFTLHDDDR LLFRADPEPG DLFDALHARL ARVMGRDFIE NAIRIDTERE
GVRLQGFAAL PTYSRGAAVA QHLFVNNRPV RDKLLTGALR AGYFDVLPGG RHPAAVLFVG
CDPHFVDVNV HPAKAEVRFR QPDLVRGLVV STLRHRLAGE SRRASDTVGA ATLAAFRSDS
ARPMVRGYQM EYRPSTGAIR TAMAGQAPQG FGGDPGFDGF AEAPSGRVEE APEGGTDAPL
GAARAQLHQN YIIAQTADGM IIVDQHAAHE RLVYERLKVQ AEQTGIASQA LLIPEIVELP
EACAARILAV AEDLARLGLH VESFGGNAVA VREIPALLGR LDAAALIRDI ADDLADQGAS
DRLRARVDAV LSSMACHGSV RSGRRMTADE MNALLREMER TPRSGQCNHG RPTWVKLSLP
DIERLFGRKD
//
