ID   A0A2K9P2F6_9FIRM        Unreviewed;       532 AA.
AC   A0A2K9P2F6;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=K(+)/H(+) antiporter NhaP2 {ECO:0000313|EMBL:AUO19443.1};
GN   ORFNames=B9O19_01282 {ECO:0000313|EMBL:AUO19443.1};
OS   Monoglobus pectinilyticus.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Monoglobus.
OX   NCBI_TaxID=1981510 {ECO:0000313|EMBL:AUO19443.1, ECO:0000313|Proteomes:UP000235589};
RN   [1] {ECO:0000313|EMBL:AUO19443.1, ECO:0000313|Proteomes:UP000235589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14 {ECO:0000313|EMBL:AUO19443.1,
RC   ECO:0000313|Proteomes:UP000235589};
RA   Kim C., Rosendale D.I., Kelly W.J., Tannock G.W., Patchett M.L.,
RA   Jordens J.Z.;
RT   "Monoglobus pectinilyticus 14 draft genome.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP020991; AUO19443.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2K9P2F6; -.
DR   OrthoDB; 9810759at2; -.
DR   Proteomes; UP000235589; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 2.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR   PROSITE; PS51202; RCK_C; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000235589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        182..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        359..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          396..462
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
FT   DOMAIN          463..532
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   532 AA;  58138 MW;  C6D6013C62D401D2 CRC64;
     MPVYILIASV VIIACIILNK VTNKLGIPML LAFILLGIFF GSDGVVKIEF GNYDFAEQIC
     SAALIFIMFY GGFGTKWSEA RPVAVKAVLL SSLGVVLTAA ITGLFCHYFL KIEWLESFLI
     GSVISSTDAA SVFSILRSKR LNLKYNTASL LEVESGSNDP CSYMLTIIVL ALMEGSASGG
     GIAYLVFAQF VYSTVFGFAL AFGSVWIMKK YKFSSAGFDA AFVLAVALLA YAVPSLLGGN
     GYLCTYIVGI YMGNQEIKNK KSLVNFFDGV TGLMQMLLFF LLGLLSFPSQ MPSVILPAVA
     IALFLTFIAR PAAVFAILTP FKSNLKQRLL VSWSGLRGAA SIVFAVMATV SPASTSNDIF
     HIVFLIVLFS ILIQGSLIPL VSKKLGMIDN KINVLKTFSD YSDEVPVQYI KFKIPENHFW
     AKKKVTDIIL PPETLLVLLQ RGSDKMIPDG ETVLLPEDTL VLIAKAPGEI EGVRLTERQI
     EPDDELAGRR ISEIPKRDGM QITMIHRNGK VIIPKGYTKL KSGDLMVINR VE
//