ID A0A2K9P4B3_9FIRM Unreviewed; 888 AA.
AC A0A2K9P4B3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=B9O19_01956 {ECO:0000313|EMBL:AUO20103.1};
OS Monoglobus pectinilyticus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Monoglobus.
OX NCBI_TaxID=1981510 {ECO:0000313|EMBL:AUO20103.1, ECO:0000313|Proteomes:UP000235589};
RN [1] {ECO:0000313|EMBL:AUO20103.1, ECO:0000313|Proteomes:UP000235589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14 {ECO:0000313|EMBL:AUO20103.1,
RC ECO:0000313|Proteomes:UP000235589};
RA Kim C., Rosendale D.I., Kelly W.J., Tannock G.W., Patchett M.L.,
RA Jordens J.Z.;
RT "Monoglobus pectinilyticus 14 draft genome.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP020991; AUO20103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K9P4B3; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000235589; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000235589}.
FT DOMAIN 707..723
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 633..640
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 888 AA; 99989 MW; A8CCA56E9469D0AC CRC64;
MIIDRNNLTP MMQQYFEVKD QYNDCILLYR LGDFYEMFFD DAVIASKVLE IALTGRACGL
EERAPMCGVP FHSVDSYIVK LVNAGHNVAV CEQAEDPAEA KGLVKREVVR VITPGTIMDT
SALDDQKNNY LCSFFRSDGG IGLAFVDITT GDVYVGEYSG KNMMNLVMNV ITRFAPTEFI
MNMRAYENTD LVKTLTDKFS CFVRNYYDWS FAEEESKKAV SDQFNAVREG DGDILEELGI
NEMSMAVSAL GGILAFLKET QKAELTNIKS VEVLNDDGEM QIDMYSMRNL EITETIRERS
QRGSLLNVLN KTKTSMGGRM FRKMITAPLT NRIAIQNRLI AVDEFYKNQL FREEIIDILK
NISDIERIIT KLAYKTANCQ DLICLRNSFK RLPELKKYLE QSSSKLVREQ LKRFDDLSDL
YELIYKTIDD EAPAVLRNGK LIKKGADPEL DKIREIKQNG QDWLTGIVEE EKRKSGIKNM
KLGFNKVFGY YIEVSKQSNE NIPDYFIRKQ TLVNAERYIT PQIKELEEEI LEAGEKVNDL
EYNIFCRIRD HVAASYGRIR ETSDVIALID VLCSLAVVAE SNGYVMPTVN NSDKIIIKDG
RHPVVESISK ANVFIPNDTS MDNESNQISI ITGPNMAGKS TYMRQVAVIV LMAQMGSFVP
ASSAEIGIVD RIFTRVGASD DLSSGESTFM VEMKEVAYIL NNATKRSLII LDEIGRGTST
YDGLSIAWAV VEHIADAKKC GAKTLFATHY HELTELEDKI NNVKNYCIAV KKKGDDITFL
RKIIRGGADE SYGVEVAALA GVKKSVIIRA KEIAGILESR EQKTVNTADI KTGTKKEKKT
PFKDEQIDFF AQADNPVITQ LKELDLNTIT PVEALTKLFD LQAKAKNM
//
