ID   A0A2K9V666_9CAUD        Unreviewed;       199 AA.
AC   A0A2K9V666;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   08-NOV-2023, entry version 16.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   ORFNames=KP1_224 {ECO:0000313|EMBL:AUV57583.1};
OS   Klebsiella phage KP1.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Straboviridae; Tevenvirinae; Jiaodavirus; Jiaodavirus jd18.
OX   NCBI_TaxID=2070202 {ECO:0000313|EMBL:AUV57583.1, ECO:0000313|Proteomes:UP000240488};
RN   [1] {ECO:0000313|Proteomes:UP000240488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kim D.;
RT   "Draft genome sequence of Klebsiella pneumoniae phage KP1.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; MG751100; AUV57583.1; -; Genomic_DNA.
DR   Proteomes; UP000240488; Genome.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AUV57583.1}.
FT   DOMAIN          1..199
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   199 AA;  22163 MW;  9E21FF4B45B51C85 CRC64;
     MIQIVYAFAP TKTVDGKNEN AFGLGDGLPW KHISQDMKNF ANRTRDTILI CGAKTFMSFP
     KPLPGRKTIV VQDMSRALAT AKNGFFADAY VSELEFIGFL GGDIMAAHTS YNSTITFNRD
     LNYSIIGGAG IIQKAYPYAD RVIQTTIRKS HRVNSDVTLP AEFVAAPTCP ESGFITKENH
     WYHIDEVTNI SEVVYERKL
//