ID A0A2L0D4J9_9STRE Unreviewed; 440 AA.
AC A0A2L0D4J9;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:AUW96570.1};
GN ORFNames=C0J00_05350 {ECO:0000313|EMBL:AUW96570.1};
OS Streptococcus pluranimalium.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=82348 {ECO:0000313|EMBL:AUW96570.1, ECO:0000313|Proteomes:UP000238956};
RN [1] {ECO:0000313|EMBL:AUW96570.1, ECO:0000313|Proteomes:UP000238956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH11417 {ECO:0000313|EMBL:AUW96570.1,
RC ECO:0000313|Proteomes:UP000238956};
RA Hurst M.R.H.;
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AUW96570.1, ECO:0000313|Proteomes:UP000238956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH11417 {ECO:0000313|EMBL:AUW96570.1,
RC ECO:0000313|Proteomes:UP000238956};
RA Zhang J.-R., Hu G.-Z.;
RT "Whole genome sequencing analysis of Streptococcus pluranimalium isolated
RT from cattle infected mastitis in China.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; CP025536; AUW96570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2L0D4J9; -.
DR KEGG; splr:C0J00_05350; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000238956; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21147; RsmF_methylt_CTD1; 1.
DR Gene3D; 2.30.130.60; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR031341; Methyltr_RsmF_N.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR027391; Nol1_Nop2_Fmu_2.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR031340; RsmF_methylt_CI.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF17125; Methyltr_RsmF_N; 1.
DR Pfam; PF13636; Methyltranf_PUA; 1.
DR Pfam; PF17126; RsmF_methylt_CI; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000238956};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 1..283
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 221
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 99..105
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 123
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 168
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 440 AA; 49808 MW; EFDACE1DD2FB7610 CRC64;
MTLPQDFINK YIELLQEEAP NFLDSFSEAP VSGFRSNPLK ENQIAFDNPI PKTEWGYYGK
ISGKSVEHVT GLVYSQEPAA QMVGQVAKPK PGMKVLDLAA APGGKTTHLL SYLNNTGLLI
SNEINTKRSK ILTENVERFG ARNVLVTNES AERLAKIFPS YFDLIVFDGP CSGEGMFRKD
PEAEKYWHKD YPKELASLQK SILSDALAML APGGELVYST CTWSPEENEE VVEWLLEEFS
QLELIPIRAI NGMRDSDLMP GTVRMYPHSF KGEGQFIAKF KDVRPREEET KLKQKRKARQ
VSLTKEQMNL WESFSQEHLK ITLEGQYQVF GDQLYIIPAH LPDLSQLKIA RNGLHLGTFK
KKRFEPSFAL GIALKPSEVV QKLEIDIEQF KEYVAGSQVN LHETYSNGWY QVVINGNGLG
FAKVVGNQLK NFYPKGLRFK
//
