ID A0A2L0D7B6_9STRE Unreviewed; 738 AA.
AC A0A2L0D7B6;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:AUW97564.1};
GN ORFNames=C0J00_07340 {ECO:0000313|EMBL:AUW97564.1};
OS Streptococcus pluranimalium.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=82348 {ECO:0000313|EMBL:AUW97564.1, ECO:0000313|Proteomes:UP000238956};
RN [1] {ECO:0000313|EMBL:AUW97564.1, ECO:0000313|Proteomes:UP000238956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH11417 {ECO:0000313|EMBL:AUW97564.1,
RC ECO:0000313|Proteomes:UP000238956};
RA Hurst M.R.H.;
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AUW97564.1, ECO:0000313|Proteomes:UP000238956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH11417 {ECO:0000313|EMBL:AUW97564.1,
RC ECO:0000313|Proteomes:UP000238956};
RA Zhang J.-R., Hu G.-Z.;
RT "Whole genome sequencing analysis of Streptococcus pluranimalium isolated
RT from cattle infected mastitis in China.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP025536; AUW97564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2L0D7B6; -.
DR KEGG; splr:C0J00_07340; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000238956; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000238956};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..693
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 738 AA; 83757 MW; 587416B7D15BB71F CRC64;
MLKPIYLAFL VALTYFMILT KSWVVFLLAL LAAIALFRQY SKKAIIQTII ILTLFVAYFT
FLGNKQIQLE KQLPSQVSTL RVIPDSISVD GDLLSARAEE GKQRYQLYYQ LQTELEKEYF
QNLNQLILLK VMASVEKPQG QRNFKGFDYK TYLKREGIYG IVQVEKVNAI HTVAPQNPEE
WVRLWRRKLL VHINQHFPEP MKHYMTGLLL GYLDKSFDEM SDIYTDLGII HLFALSGMQV
GFFVGIFRTI LLRLGLLREH FLYVLLPFSF IYAGLTGFTI SVVRSLLQAI LSQFGLRKWD
NLGTTILILF LLSPHFLVTT GGVLSFAYAF ILSTIDLETL SGCRKAVVES MVLSLGILPL
LVFYFGTFQP LSILLTAFFS VIFDVFLLPL LSLVLLASPI VSLDFFNPCF YFLESVIKWT
VHLSPRPLVF GSPNLTVLLL MLISLAVVHD FWHDKKLRYC FLIVVVALFA VTKKPLENEV
TVLDIGQGDS IFIRDIRGKT LLIDTGGRVD FTQKEEWRRR QKTANAERTS IPYLKSRGIS
SIDQLVITHT DADHMGDLAV LAKQFSIKKV LVSPGALTNP SFVNELKSLK IKVGLLQAGD
QIAIMGSSLR VLYPWDQGDG GNNDSLVLYG KLLDKRFLFT GDLEVDGEKS LMMRYPNLPV
DILKAGHHGS KGSSDPDFLK HIGAKVVLIS AGLNNRYQHP NDETLERFEA EKMMVYRTDQ
EGAIRYRGVK TWKVETVR
//
