ID   A0A2L0EUV9_SORCE        Unreviewed;       228 AA.
AC   A0A2L0EUV9;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Protein GrpE {ECO:0000256|RuleBase:RU000639};
GN   ORFNames=SOCE26_044950 {ECO:0000313|EMBL:AUX43055.1};
OS   Sorangium cellulosum (Polyangium cellulosum).
OC   Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX   NCBI_TaxID=56 {ECO:0000313|EMBL:AUX43055.1, ECO:0000313|Proteomes:UP000238348};
RN   [1] {ECO:0000313|EMBL:AUX43055.1, ECO:0000313|Proteomes:UP000238348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=So ce26 {ECO:0000313|EMBL:AUX43055.1,
RC   ECO:0000313|Proteomes:UP000238348};
RA   Zaburannyi N., Bunk B., Overmann J., Mueller R.;
RT   "Sorangium comparison.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates actively in the response to hyperosmotic and
CC       heat shock by preventing the aggregation of stress-denatured proteins,
CC       in association with DnaK and GrpE. It is the nucleotide exchange factor
CC       for DnaK and may function as a thermosensor. Unfolded proteins bind
CC       initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK
CC       hydrolyzes its bound ATP, resulting in the formation of a stable
CC       complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the
CC       release of the substrate protein, thus completing the reaction cycle.
CC       Several rounds of ATP-dependent interactions between DnaJ, DnaK and
CC       GrpE are required for fully efficient folding.
CC       {ECO:0000256|RuleBase:RU000639}.
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DR   EMBL; CP012673; AUX43055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L0EUV9; -.
DR   Proteomes; UP000238348; Chromosome.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   Gene3D; 2.30.22.10; Head domain of nucleotide exchange factor GrpE; 1.
DR   InterPro; IPR000740; GrpE.
DR   InterPro; IPR009012; GrpE_head.
DR   PANTHER; PTHR21237; GRPE PROTEIN; 1.
DR   PANTHER; PTHR21237:SF23; GRPE PROTEIN HOMOLOG, MITOCHONDRIAL; 1.
DR   Pfam; PF01025; GrpE; 1.
DR   SUPFAM; SSF51064; Head domain of nucleotide exchange factor GrpE; 1.
DR   PROSITE; PS01071; GRPE; 1.
PE   4: Predicted;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU000639};
KW   Stress response {ECO:0000256|RuleBase:RU000639}.
SQ   SEQUENCE   228 AA;  23716 MW;  0F37B328B23E57EC CRC64;
     MMEETPAGAP PEDIGARLTE LVREVRRQGR AAVAAQAAAE SCLEQVTALA RAAESARDAG
     GAPRPAEELS WLGVILPVAD AIDRAVAQAS AMVERRARVE RAGFWPFRRR AEPDPELGAL
     AEGLRVLRAQ LVAALEGCGV TVDRRVGVAV DPEVHRVVEV RPPRDAEPEG VVVDVIRPGY
     AARGRLVREA DVVASGAPLV VGAGAEAQHL REVAADLEGA GQGGGGGS
//