ID A0A2L0EWC8_SORCE Unreviewed; 4952 AA.
AC A0A2L0EWC8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SOCE26_050540 {ECO:0000313|EMBL:AUX43604.1};
OS Sorangium cellulosum (Polyangium cellulosum).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=56 {ECO:0000313|EMBL:AUX43604.1, ECO:0000313|Proteomes:UP000238348};
RN [1] {ECO:0000313|EMBL:AUX43604.1, ECO:0000313|Proteomes:UP000238348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce26 {ECO:0000313|EMBL:AUX43604.1,
RC ECO:0000313|Proteomes:UP000238348};
RA Zaburannyi N., Bunk B., Overmann J., Mueller R.;
RT "Sorangium comparison.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012673; AUX43604.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000238348; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00743; FMO-like; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR PRINTS; PR00370; FMOXYGENASE.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..450
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1806..1887
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2318..2745
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3721..3797
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3857..4289
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 804..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1779..1806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1900..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2286..2313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2918..2938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3815..3852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4389..4413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4469..4492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1904..1929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2918..2937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4952 AA; 526895 MW; 8148D3237F12F744 CRC64;
MVPSHEGEAH VEPEDVAVIG IACRFPGAAD HRAYWRNIEA SVVSVDEIPS ARWDWRSLCR
EAGLEENGSP LRWGGFLDEI DLFDPEFFSI SPREAHAMDP QQRIMLQLAW ACLEDAGYPA
SRVKGTNVGI FVGVCNYDYK ELQDRCGETI GGHTLTGTAN TIVPNRISYE LDLHGPSVST
DTACSSSLYA IHEAVSSLRR GECGMALAGG VNLLACGERY VSMAKLGMLS SAGLCNTFDA
DADGYVRAEG AGLVLLKPLE RALHDRDFIY GVIKGSAVNH GGRARTLTAP NTFAQSRVLA
AAWKRAGVSP ETLGYIEAHG TGTPLGDPIE MHGLLRAFGQ LARGSGAAQP EKPTCGIGSI
KANIGHAEAA AGIAGVIKVL LAFQHGVRPG MPRFRRINPR IKLEGKPLFV VDKSQPWERL
RDADGNPQPR RAGVSSFGFG GANAHVVLEE RLAPEDPVRD AQTTGPAVVP LSAKNPERLR
EMAGALASFL AERRGSVDLR DVAHTLQIGR EPMASRAAVI AADLDALIAG LDAVARGVEE
APGVLRGEVS ERKEEAAVAR SDGGEAAAPA EIASRWVHGG DVDWAAADPG AQGRRIPLPT
YPFARHRYWL PGLRSPAPSA REGAAPGAAR PAIGRPCPLH EGRCTLIEIE PSDPRLRDHV
VDGRPIAPAA LTLDLVAAVA RAGGAAPIRL REVSWIRPLE SAAGAALACH VELTPRGDEL
AFEIFTVPGG AGREVSCRGI VDPRPATGGA PERRDVAAIE ARCAAREGAA ARYSALGLVG
LDYGATYRVL RRLSWSDREA LGALEAPQPA PGDRAREPGA SPLRPDILDG ALQTASALLD
LEAYGAPLPA ELALIEVHAP LPREGFVHVA RGGAGADCFD LEILDGAGAV CAALRGLAIV
RRRAARPGMF YRPAFRPLER RDDVVPEAGE GSVLLVGLAP QRDLMLRIAA EHRGEQARVI
VLGDHTAPVS PREWTLAPAD AEGLARCLDG LGGVRALYFL GALSDPASPP DDLDAIERCQ
ARGALTLLRF VQALDRKSLL RDGTAIRAFT NGAFAVSPAD EVVPHGASVV GLALSIAREH
PALRVTCADL PAVIEADDAL VSAMTRRDLP PFAVTAIRGG VHLARALEPL RLERGELALR
PRGVYLILGG ASGIGLETAV LFAERARARV AVVGRRPLDA ELSRRLERVR SAGGEVLYCQ
ADGASRADME RAVREVWDTF GPINGVVHSA VELADRPLEG MDDAAFRAAL APKVQASVVL
AAVTAREPLD FTVFYSSAIS YRGNAGQGNY AAGCTFQESL AARLRKAGRR VQVVSWGFWG
ETGVVAGEGW LRKLARLGIR PISPAEGVDA IARILASPID EVVALRADRA ALADFGVREG
APVAAGAPAR ASEGALDLSS LARASEDAPA LARQVEAFRE LEELGGLGLI EALEALGALG
EGASSPARAG LRERLAPAPG FERLADAMLE LLRRAGHLEG AGGSLRLSER SREHLARRSH
RALVEGFAAF ERRHPDLLPH ARLLGACIEA LPSVVRGERL ATDVLFAPET RPHVERVYRE
GAVGAYGRAA ASAVREIVAR RAASSTSPIR LIEVGAGTGG TTGHVIAALA GAPGRVEYVY
TDVSPAFLRL GEERFGPRHA PMRFARLDIE AHPEDQGFDR GSADIVLAAN VLHATRDVAE
TLRHLKWLLA AGGHLLLCET REVQLFTTLT FGLLDGWWRF TDPERRLPHA PLLDVARWRR
ELAERGFRAI QAASLTGDEH EPLAQCLIAA ESDGAVAARA PAPAAARAER PEARRSEPAP
ERAGADSAAS LKAAVLELVL GELARATQRA PAGIDAERPF AELGVDSIVG ADVAQGLSRA
MGLPLKTTSL FEFPTAAALA EHLCAAHPAA LRARLGVAEP PARPAPAERR EEPPARSASA
ERREEPPARP APPAEASVVA RVPRAIAARG ETCPGVVLHM PGSIDDVHVE PVVVGPPGPG
EVQIRVHAFA LNFGDLLCVR GLYPTMPEYP FVPGFEVAGT VHRVGSEVDG LRPGDEVVAL
TGAALGGHAA LVNTPAIVTV KKPRGLRFDE AAALPVAFVT AHAALELAAP VAGERILIQT
AAGGVGAMAV QLAQQRGLEI FATAGSAEKC EHLRRQGVAL AIDYRATDFA RAISERTGGQ
GVDIVLNMLP GDALQKGLDL LAPGGRYVEI AMTALQQARA VDLSRLVANQ SIVSVDLRRT
LLSRPARVRR ALEEMVALVE AGRLRPNVGR TFAFDDWREA YRYLDGARNV GKVVVTGVAL
DRERAAASPE RAAASREPRG PSPELGAAGA ARAERPELEP IAIVGASGRF PGAADLEAFW
RNLAAGVCSV TRARVEDWPI AIRDIPGAGD DVAPAALYGG YLEDIDRFDP LFFRISGAEA
VLMDPQQRLF LEESWKALED AAIAPSSLDG QRCGIFLGAA PGDYDDVLGA AGERIEAHTF
TGNEASIGAA RLAYLLNLKG PTLTIGTACS SSLVALHYAC QSLRGGECDL ALVGGAFVNT
TPRFHVLASR AGMLSPNGRC RTFDEGADGF VPGEGVGVLV LKPLARALAD RDLIRGVIVA
TGVNQDGRTS GITAPSAAAQ VALLESVHEA GGVDPGTIEL MECHGTGTPL GDPIEMSALT
RAFRSDAGAP RACAVGSVKT NIGHTVTAAG VAGVLKALLA IERRALPPTL HFERLNPRID
LEGSPFFVNT ELRPWPPSGD PRRPRRAAVS SFGFSGTNAH AVIEEPPPMP ARSGEPSGRE
PFCFCLSATT GEALRRRSGD LLAWIQRHGR EHRAGDVSFT LLSGRSHHPE RLALVARDLD
ELAAQLEDEL AGRPVARARR GARSEDPRAR AVDGERCRRI VAELEEAARD RGALMVELAE
LYVRGADAEL RALFQAGDFR RVRLPAYPFA QERYWPRGAR RRSAGEPRSE RGGAHPLVDR
RLANGGAPLF EKTFTPGDAW VRDHLVWGQP TAPGAVFLEM ARAAAAQAGA EVRRISSATW
LQPLQVAAGP VAVAIHLEPQ PAGGALRCQM TSGEGRAVHV DLQLSPAPAH APPPLDLASI
RRRLPERLSG DACRSRLLGH GLAFGPALRA LKEVLRSGDE ALAAFEPGLD GDLEGDGLVL
LPSIIDGAWQ ALVALLPSDE PAPFRPFSLE GFTWYEPLGR AAFVHIARSG PEAGRYLRFS
LAFADATGRV LAQMDHFTVA RAEAPAPRAL AREAAAAGGA SSLFFEPVWR SMDPGADPSA
RAPRRVLVID GDDDDGLRDA LASRLGRLSP GGAPDVARIS LAERGEGDED PGLERAIERA
RPELIVACWP SRLGSPPGWS GEGAEDALRR RALPFYRLSR ALSRLGAGVR LMCVRAGSRD
TSAPFFEALA GLLRTLTLEQ PACAAQLIAL DGAPSAGPEE ISDVVLREWA AAAPLAREIR
YAEGQRQVRD LAEWRPQAGG AAPSPWRRGG VYLVAGGAGG IGRVVAEHLA REAEARLVLL
GRSELGGDAQ RWLDGLKRLG GSATYTRVDV TRREDVRAAV EQARDRHGAL HGVVHAAGVL
RDGLLARKAE RDVEAVLRAK VLGAVHLDEA VADGPLDLFV LFSSLAGLTG NEGQADYAYA
NRFLAGFAAW REARCSEGAR SGRTLAVDWP LWAEGGFAIP GPVRERMAAV AGLLPMPAEA
GLAALRACLQ RPGPSLSVMY GREATMRVFL SGFREHALAG PASAPVASAG AGGAERAVGA
ELHAAAERLL QERFAELLQI PASRLRPDEP FERYGIDSMM AARITSRLED DLGELPKTLL
FEHQSLASLA RCLVAEHGAK LAALSAARPA PAAATSTPAA EPAATSAPVA TSAPAAATSV
HPGPEGAGPT PDRARAFEDI AIIGLAGRYP KAPDLDTFWQ NLVEGRDCIE EIPPERWDVA
RYADMDPSRT ERPHGKWGGF VADHDMFDPL FFHIAPREAE VMDPQERLFL EIAWAALEDA
GYSRSTARRA FDRRIGVFAG VMWSDYQLYG VGQGADGRGL RLSSSFASIA NRVSFALDAT
GPSMAVDTMC SSSLTAVILA CQSLSRGECH AAIAGGVNLS LHPNKFVYLA QQKFLSSDGR
CRSFGEGGDG YVPGEGVGAV VLKPLRRAVA DGDHIYGVIK GAALNHGGMT HGYTVPNPDA
QAALIREALE TSGIDPATLG YIEAHGTGTA LGDPIELRAL ARALGGARPG GPLCAVGSVK
SNIGHLESAA GIAGLTKVLL QLRHRLLVPS IHADTLNRNV DFGALPLWVQ RELAPWEHPA
SGARGGHPRR AGLSSFGAGG ANAHVVVEEH LADEGAAPRA GAGSPELLPL SAATEERLVA
YAQSLLGFIA RARRSGEPLP SLADIAYTLQ VGREPLDRRL AIVATDIARW EDSLARFVAG
ERAIQGMYLG SPGEAPPPGA PEGAGGAPES AGLLAMGRPL SEPELALLAA RWVSSQDEVD
WTALPRSGRP RRVSLPTYPF ARRRCWAPRR PADEPARSAA APEAKPARPS VKAPALGRRA
DAYCIIGGGP TGIGTAKCLL QRGVPVEIIE REDDFGGVWN FGAPSGRVYE STHLISSKLN
TQFSDYPMPE EYPHYPDRRM FLRYLRDMAR HFGLYDRARL RTSVERIEPE GDAWRVVTSD
GDARLYRGVV VANGLQRKPK YPDLPGTFTG ETLHTADYRS SSSLRGKRVL IIGGGNSGCD
IAVDVCSAAA AVFHSMRRPY YFMPKFIEGR PTQEWLMDLP RRLGEGVDVW PHVSRVFKLA
GFDPADYGLG APEYRIDQAH PVINSHYLCH VGQGDIVPKR DVASLDGRRV TFTDGSAVEV
DCILYATGYT PHFPFLDERH LRWTNGRPDM FLRMFHREYD NLFLVGFVNA AAGLGNVVNA
MGNLLAAYLR AREQQTPGFR RFRALVSGPD PDLGEQNFLR SDRHAFEVDL WKMIRAISFF
RAKLEVAATD APSGSSVAVT PLQTPHENTG NP
//
