ID   A0A2L0PN65_VITS1        Unreviewed;       371 AA.
AC   A0A2L0PN65;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=ADP71_22460 {ECO:0000313|EMBL:AUZ05634.1};
OS   Vitreoscilla sp. (strain C1).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Vitreoscilla.
OX   NCBI_TaxID=96942 {ECO:0000313|EMBL:AUZ05634.1, ECO:0000313|Proteomes:UP000238938};
RN   [1] {ECO:0000313|Proteomes:UP000238938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C1 {ECO:0000313|Proteomes:UP000238938};
RA   Veseli I.A., Stark B.C., Pombert J.-F., Juarez O.;
RT   "Genetic Analysis of ATP Synthesis in Vitreoscilla sp. C1.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR   EMBL; CP019644; AUZ05634.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L0PN65; -.
DR   KEGG; vit:ADP71_22460; -.
DR   OrthoDB; 9790967at2; -.
DR   Proteomes; UP000238938; Chromosome.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AUZ05634.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238938}.
FT   DOMAIN          20..354
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   371 AA;  41000 MW;  B843F25FEC16B227 CRC64;
     MDMPLVLFST IPTSHNQFIA IATLNRPKAL NAQNTALIIQ LRQQLETWQN DDSIAMIWLD
     GSGDKAFCAG GDIRELRQGV VDAPNEQQAH EHVHEFFAAE YYLCEYLSRY PKPVVCWASG
     IVMGGGMGLA NAASHTIVTE TTMMAMPEIS IGLYPDAGGT WFLQKFPFGS GRFLGLTGAR
     FNGRDALLGN LAAYSRPSDS RQETLEALIA ADWSMPAHQV VRQTLNPLQA AALPESQILA
     NHAVLQEIVS QATFQDALTI LAHNHADNNW LAQAHENTQN GCPTSMGLIW RLMEDLKHAS
     LAECIEQELI VSQQCCTRPD FLEGVRALLI DKDKNPQWVK SIAQVNRAWL DTFFESSEYL
     AKTSIESVTL A
//