ID A0A2L2T4J8_9HYPO Unreviewed; 226 AA.
AC A0A2L2T4J8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
OS Fusarium venenatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=56646 {ECO:0000313|EMBL:CEI42070.1, ECO:0000313|Proteomes:UP000245910};
RN [1] {ECO:0000313|Proteomes:UP000245910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3/5 {ECO:0000313|Proteomes:UP000245910};
RA King R.;
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
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DR EMBL; LN649232; CEI42070.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2L2T4J8; -.
DR STRING; 56646.A0A2L2T4J8; -.
DR OrthoDB; 4342at2759; -.
DR Proteomes; UP000245910; Chromosome iiii.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245910};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 27..222
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 226 AA; 24383 MW; CB8914229F647FFC CRC64;
MAPKVLVVLT SQSKMNNGNP TGWYLPELAH PYYDLVNAGV EIVTASPAGG EAPLDQGSVE
MFKADEESVK FLNEKKQVWE QTAPLKEFLD KSSEYDAIFY PGGHGPMFDL VNDETSIKLI
EEFYKAGKPV ASVCHGPIVF TQVKIDGKPL LEGREATGFS NSEEEAVGLT SSMPVLLEDE
IKRVGGKYVK ADDWAEKLVV DGQVITGQNP ASAHAVGKAI LKAIGA
//
