ID   A0A2L2T5P9_9HYPO        Unreviewed;       373 AA.
AC   A0A2L2T5P9;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
OS   Fusarium venenatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=56646 {ECO:0000313|EMBL:CEI64969.1, ECO:0000313|Proteomes:UP000245910};
RN   [1] {ECO:0000313|Proteomes:UP000245910}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3/5 {ECO:0000313|Proteomes:UP000245910};
RA   King R.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; LN649229; CEI64969.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L2T5P9; -.
DR   STRING; 56646.A0A2L2T5P9; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000245910; Chromosome i.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245910}.
FT   DOMAIN          15..287
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   373 AA;  41304 MW;  19B9B3E00D7F6A90 CRC64;
     MTEKTTSRGP LGRVVVIGGN GFLGHHIVNQ ALENWTTTAT IGVDLRCERN RNPNAEYHEC
     DITDSERLLS LFEELKPDVV IHTASPVAVN PKIGNDVFKK VNVDGTQAVV DACQKTGVKA
     LVYTSSASVI SDNVTDLLNA DERWPLIRGD QQTEYYSETK AQAEEIVIKA NRQDDSKLLT
     TSIRPAGIFG EGDVQTLAGI LNAYKRGKHT IQVGTNENLF DFTYVGNVAH AHLLAAQLLL
     ATAASSTVPL DHERVDGEAF FITNDTPVYF WDFARTIWHA AGYDKGTEPN WYLNRELGIA
     FGYISEVIAS ILGKTPTLTR KAIIMSCMTR YYNINKAKRA LRYQPLWTLK EGIDRGVNWF
     LEQDKAAAAP VKA
//