ID   A0A2L2TC45_9HYPO        Unreviewed;       863 AA.
AC   A0A2L2TC45;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Ergothioneine biosynthesis protein 1 {ECO:0008006|Google:ProtNLM};
OS   Fusarium venenatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=56646 {ECO:0000313|EMBL:CEI68564.1, ECO:0000313|Proteomes:UP000245910};
RN   [1] {ECO:0000313|Proteomes:UP000245910}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3/5 {ECO:0000313|Proteomes:UP000245910};
RA   King R.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037882}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LN649231; CEI68564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L2TC45; -.
DR   STRING; 56646.A0A2L2TC45; -.
DR   OrthoDB; 1416at2759; -.
DR   Proteomes; UP000245910; Chromosome iii.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024775; DinB-like.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR03439; methyl_EasF; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF12867; DinB_2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245910};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          55..345
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   DOMAIN          381..506
FT                   /note="DinB-like"
FT                   /evidence="ECO:0000259|Pfam:PF12867"
FT   DOMAIN          566..861
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..648
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   863 AA;  97150 MW;  002C0E9B56F28AB5 CRC64;
     MPSLTASSAA AAAPPSVKQN GSIPTPSPPS IIDIRGEYVE MNLKDEIATS FNPENGPRKL
     PTLLLYNEKG LQLFEDITYL DEYYLTNYEI EILKKNSAAI ASQIPEGSMV IELGSGNLRK
     ICLLLQAFEE AKKPIQYFAL DLSLKELERT LAQVPDFNYV SCHGLLGTYD DGREWLKHPS
     LTSRSKCIIH LGSSIGNFTR DEAADFLGGF AEVLTPSDSM IVAVDSCTMH TTFLNTDSKG
     VTHQFILNGL ENANEILGEE VFNPSEWKVI GEYVYDIEGG RHQAFLAPTR PTDVLGSRIM
     PHERVWIEQS LKYSEKEKTK LWKLAGLTET GYWSRGDEYG LHLLKKSSMP FSLIPSLYAA
     KPLPTVQDWE ALWKAWDIVT KDMIADEELQ EKPIKLRNAC IFYLGHIPTF LDIQLTKTTG
     QPPTDPTSYY SIFERGIDPD VDNPEHCHSH SEIPAEWPPV QEITLYQDRV RSRLQKLYEN
     GQDKIPREIG RAIWVGFEHE LMHIETLLYM MLQSSKTLPP PHTVQPDFAK MAQQAYKARV
     PNQWFDVPEQ TIMLGMDDPE DGTDPSRHFG WDNEKPARQA NVHAFQAQGR PITNEEYAQY
     LYNSKIDRVP VSWSSVPSNK QDGATNGHHT NGHSNGYTNG NGNGHHANSV PDSFIEGKFV
     RTMYGLVPLK YALDWPVFAS YDELVGCAAW MGGRIPTFEE AKSIYAHVDK QKKAEAERIL
     SKTVPAVNGH LVNDGVEETP PSNSSALVKD SSSELFFDLT DANVGFRHWH PMPVTSRGNK
     LAGQAEMGGV WEWTSSILER HEGFEPMSLY PLYTTDFFDG KHNIVLGGSW ATHPRIAGRA
     SFVNWYQRNY PYAWVGARLV RDI
//