ID   A0A2L2TX53_9HYPO        Unreviewed;       768 AA.
AC   A0A2L2TX53;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
OS   Fusarium venenatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=56646 {ECO:0000313|EMBL:CEI65235.1, ECO:0000313|Proteomes:UP000245910};
RN   [1] {ECO:0000313|Proteomes:UP000245910}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3/5 {ECO:0000313|Proteomes:UP000245910};
RA   King R.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004128}.
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DR   EMBL; LN649229; CEI65235.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L2TX53; -.
DR   STRING; 56646.A0A2L2TX53; -.
DR   OrthoDB; 11387at2759; -.
DR   Proteomes; UP000245910; Chromosome i.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14480; SPX_VTC2_like; 1.
DR   Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR   InterPro; IPR003807; DUF202.
DR   InterPro; IPR004331; SPX_dom.
DR   InterPro; IPR018966; VTC_domain.
DR   InterPro; IPR042267; VTC_sf.
DR   PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR   PANTHER; PTHR46140:SF2; VACUOLAR TRANSPORTER CHAPERONE 2-RELATED; 1.
DR   Pfam; PF02656; DUF202; 1.
DR   Pfam; PF09359; VTC; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245910};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT   TRANSMEM        682..703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        724..745
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..156
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   REGION          571..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   768 AA;  88328 MW;  38965C47597BF1CB CRC64;
     MRFGRTLRES VYPPWKDKYI EYAKLKSLLR EDVADDDNQP WTDEDETRFC EEIFNNQLEK
     VAQFQEQRFN ALKDRIDSSF DKLKELAPVE SKEDGGPSKG DISATRLRAL ESELDEITNE
     VRELKKYSQI NYTGFLKIIK KHDRKRGDRY KVRPVMQLSL SQRPFNSEAG YSPLLNKLSI
     MYFAIRQQLE ETGEQLPPLD LESQGEMYNG ERYTAHKFWV HPDNLLEVKT VILRHLPALV
     YSEKSAKELD GSDSPSITSL YFDNKKFELY GEKVDRQSEA TSLRLRWYGQ LATRPEIFVE
     EKTVDEKGGS QDLKFSIKDK YVKSFVDGEY KTEKAVQKLK RQSFAPEKIQ EFEQTVGTIQ
     KYLKEKDLSP VLRANYVRTA FQKPADDRIR IAIDTNVAFI REDTLDRSRP CRDPKEWHRL
     DIDDSEMTYP FKNINQSEVN RFPYALLEIK LKDDGQRKRP TWIEDLMVSH LVHPTPRFSK
     FVHGIAVLFE DYVNSLPFWL SDLASDIRKD PQKTFEEEEQ RRAQRHEDVM AVGSLIGAGA
     KSGSYKPTQS SPVSKSYLAD RMSKDSIAHK LNKQASTPGN GEEVGESSGQ RQEEQGRSYG
     TLSSVIPGFS LSKYSRAKRA SQQPLPEGVV APTQWIKNMG ELKVEPKVWL ANERTFLKWQ
     HICILQGGLA VGLYTAAGEN TVASVIGLLF VLIAVFAGAW GYAMLRIRRT MILERSGKDF
     DNMIGPMIIS VSLMFVLILN FFFAWREAYG RFNNGNNDAG ELLSEELR
//