ID A0A2L2U367_9HYPO Unreviewed; 3960 AA.
AC A0A2L2U367;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Fusarium venenatum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=56646 {ECO:0000313|EMBL:CEI70300.1, ECO:0000313|Proteomes:UP000245910};
RN [1] {ECO:0000313|Proteomes:UP000245910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3/5 {ECO:0000313|Proteomes:UP000245910};
RA King R.;
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000256|ARBA:ARBA00004685}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; LN649231; CEI70300.1; -; Genomic_DNA.
DR STRING; 56646.A0A2L2U367; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000245910; Chromosome iii.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245910};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..440
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2397..2474
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3518..3594
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2509..2567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3960 AA; 432934 MW; 161CB99B97FF53B3 CRC64;
MAQDSQYREP IAIIGSSCRF PGSSSSPSKL WDLLHQPRDV IKTFDAERLN LARFYHENGD
THGSTDVAAK SYLLEEDNRL FDTSFFGISP MEAAGMDPQQ RILLETVYEA FEAAGLTLEQ
LRGSLTSVHV GVMTSDWANI QARDTETISK YNATGSANSI MSNRISYVFD LKGPSETIDT
ACSSSLVAVH NAALGLLNGD SDTAVVAGVN LILDPAPYIN ESKLHMLSPD SRSRMWDKAA
NGYARGEGAG AVLLKTLSQA LKDGDDIEGV IRATGVNSDG QSPGITMPFA PTQTALIRKT
YARAGLDPKK DRPQYFECHG TGTPAGDPVE ARAISDAFTG GDMSVENPLY VGSIKTVIGH
LEGGAGLAGV LKVLLALKHR VIPPNLLFNE LNPSVAPFYG PLQIPTTAIP WPELPDGVPA
RASVNSFGFG GTNAHVIIES YEDTPDEPSL HENEGILGPL VLSAKSGASL LRTVETYRNH
TQSNPTLDIA ALSAVLQERR STHRVRAHFS GSSREAIMSD MEEFLSKYGK ATGDNIGHVP
KLVNPRERSG ILGVFTGQGA QWPAMGRELI HSSPIFRRTI EECEDVLADL PEKNRPQWSL
IKELTADAST SRVAEAAISQ PLCTAVQLAL LSLLTVSGIK FDAVVGHSSG EIGATYAAGI
ISLKGAMQIS YYRGLHAKLA SGTDGKRGGM MAAGLSPMQA REFIARPDFK GRIGIAACNA
PRTVTLSGDL DAIAEAKLVL DKDNVFAREL KVDTAYHSHH MLPCAEPYLQ DLLACDIEVK
QPQQGQCVWN SSVRGDTQLL RGDLTSLKGQ YWVDNMVRTV LFSQAIESSI WHGGPYDLIV
EVGPHPALKG PAEQVMKASY GSVPVYTGVL DRKKTAIDSF SAAIGLTWAQ LGPGFVDFTN
YRNAFYKSNT SPPVRMIKDL PTYSWDHDKV YWREGRMSRR FRLGKDTSHE LLGRRTLDDN
EFELRWRNVL KLNEMPWLRG HTVLDEVLLP GASYVSIAVE AGRYLAADAD KNLGVVEVEN
IEILRPVVVP DNNAGVETLF TARLVEKSKD VIKARFSYYV CPDETVGSML QTCMGDLIVH
IKSETISNGS ALPPRDQTPP NLANISNEQV YSLFNSIGLS YTGAFKSITD INRCLNYAST
TSTWEADTLG DKYMLHPAVL DVAFQTLFVA KAHPASRQIT SALLPSHIDR VRVDPSVQIV
RPGVSKAEIE TWAISQTATS LRGDLNIYDS ASGATFLQVE GLAVNMVGAV EGASDRSMFS
KTIWGNDASL GLLDPKRNEA QDEKGMKMAD AVERVAMFYV KRIVDQIPPS EREEFIWYHQ
RMFEAFEEHI RVVAAGEHPI IKADWLNDDV SILKTIDAQY SEEIDIKLLH AVGGHLAEVV
RGNEQLLEVM TKDDMLNRFY MEGYASITTN KFVGDIMKQL TFKFPRAKVL EIGAGTGGTS
WSILNAIDDA YDSYTYTDIS SGFFPNAAEK FSSFSHKMIF KVLNVEDEPS GQGFEDGSYD
IIVAALVLHA THDLKRTLHN TRKLLKPGGY LVLLELTGIA SVRATFIMGG LEGWWLGGDD
GRRLTPLVTT VEWDNVLQDS GFSGADTVVY DLPDEAKHCT SVIVSQAIDD EFLRLREPLS
CKSDFPSLTD PLVIIGGKKF WTSKVISEVQ KLLPRSWKRQ IKLVKSIDKI DASNLPSRMD
VILLQDADES VFATTIAQPQ LNNLQAILMR SKNMLWVTTS GKSHAPRASL IQGITRVIPA
ELPHLNAQLL GMPSEQTPTS AANHTVEAFL RLIQGEDVAR DGKILWAQES ELEISADGKT
VIPRVIPDET LNETYNGSKR VISKNVDATE LAVCTEVVDG KVAMLSVDEQ DEGDGVRVDV
HSTLHLPGFD DQSIYIIFGK TDSSWVVGLS HTNCSVLYLN SEILVAVKED TTHAQLASIA
FTILARSIAV ISSTGSPVLF YNVDESFVRI IASEFGTRQL QAQFATSRAE APTDWIKIHP
LASQRAIQRA IPQNTAVFID CSAGTASMAF TFTASIPANY QMCRLGSGLL SKALEMSKMT
TATFLGQCIE AASNQKVPET EVIPASDIAG SNASVLGLRT FITDWTDKTA LPITVKPLQA
QTLFKPDRTY LMAGMAGGLG LSICEWALRN GAKHMVITSR NPQLPKATLQ EAHRLGATVK
VLPMDLTDKL SVKAAVAGIE ESMPKIAGVC NAAMVLKDGF FIDMDAEQLN NTLAAKVLGT
EHLDSIFHDT DLDFFICLGS VASVIGNVGQ SNYHAANLFM DSLINQRRNR GLAASIIHIA
YVTDVGYVTR EERDRQLDSH FRKVRLMPTS ETDVHHAFME AIRGGRPDSV SGSHDIIMGI
EPLTEPVPLD QQPLWMKDPR FGHFAPPSSV HYQQESGAAG SAGNIRQCVE EADGDEQAVA
AVIQAFCGKL ETMLQLASGS VNVSRPIIDL GIDSLVAVEI RTWFLKELGA DIPVVKILGG
DTVEQVSTLA TKKLMARILE TKAAQPQEVK PKPEPEKAAP VPVPAIQTSL ESSAVPSASS
QSVASSSRAS RDSSPSATSR SDTSATKQDM KSSTILTDDS SSDTGSLDLV REYPMSHAQS
RMWFITQHSD DPSAYNMVFR YQVKGQVSTT RLRHAVSTTA HHHEVLRTCF FARVGDGHPM
QGILASPRIK LKHVAIEQDA DVDTEMKRLS SQSWDLERGD TFELVLMSRD SENHELFVAY
HHILMDVVGL GIMIRDLNVS YQMKLLNRNA ASYLDYSSTQ LSRNELYQRL SFWKSEFATF
PEPLPLLPMA SVTTRPNNTS NNCHHQYREI RPDQFQVLAS TCQRLRISQF HFHLAIFQVL
LARYTGTEDV CIGIVDANRS DPKFAETVGY FVNMLPIRAS ITQDANFSEI ARSISQKTLK
ILSESALPFD VLLNELQVPR SASRTPLFQA ALNYRMGSIW EMPFGDAEMK LSDVKDADNP
YDLSLGIAET PTGCVVELYA LASLYSEDAC ATILESYIRL LDAFSQTPDR TVDGVGVHEE
TQVVRAIELG SGPVVEYEWA PTLSQRFRDI VQLYPDQLAI KDSCMELTYS KLNDRVQNVA
NTLLHEGFTE GSCVAVLCEP SLDFVISMLA ILHIGGIYMP LDPALIIYHS ATEGRANILR
SVGNTQFQEV PLDNIDHDSS VHVACTAKID APAVLLFTSG STGKPKGITL SQANFVNHLA
LKNDLLRLEQ ETVLQQSSLG FDMSLIQTFC ALTNGGRLVI APSDLRRDPV ALSNLLSQEQ
VTLTIATPSE YLAWFRYGYA SLVENQGWKH ACMGGEQVTR QLKNEFARLG HAGLQLTNCY
GPTEITAAAT FQTILLSDSD NNDDLAVGKA LPNYSVRILD ASGQPQPLGH IGEICIGGAG
VAIGYLDLPA ETSRKFVADS NGQRFYRTGD RGRLLPNGTL LYLGRLEGDT QIKLRGLRIE
LEEVEAALVK ASDGLFAGAV VSRHGDVLVS HVTLVAGNEM IDQERVTQIL SSVKLPQYSI
PASIAVLSTF PTTPNGKIDR KAIAATPASE SSSTMPMEKM TVREGELRLL WERVLVTSTR
IAPSSDFFLL GGNSLLLMKL QAAIRETMMA PVSTRVLYQA STLRGMAQAI DKLRQERATG
DIESEIDWDA ETAIPQWLVR QLDGATSSQK GRAPKTMGIE IMMTGTTGFL GGHLLQSLLA
SEAVNKVHCI AVPADYEASL PHNEKIIHYS GSLLSPTLGL TSEQREELAK TIDVIIHAGS
NGHCLNTYDS LRTPNVESTH FLASMAATKR IPLLFLSSNR VVLLSGNQAP PPSSVSEFYP
STDGLEGHMM TRWASEAFLE KLAQHVQNTG SYWPVSIHRP AVVVSGQAPN SDALNAILRF
SISMRCVPRL DRVEGYMDLA PLDKVVAELS EAAINLAQGQ SGNVATIQFK HHSSGVKVSA
SKLREHLEGS YGVQFEELEL RQWMDRAAVA GMDPLITAYM EGILENDAPM VFPYMGELGQ
//
