ID A0A2M8IXQ2_9RHOB Unreviewed; 647 AA.
AC A0A2M8IXQ2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:PJE35310.1};
GN Name=mrdA {ECO:0000313|EMBL:PJE35310.1};
GN ORFNames=CVM52_17825 {ECO:0000313|EMBL:PJE35310.1};
OS Pseudooceanicola lipolyticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pseudooceanicola.
OX NCBI_TaxID=2029104 {ECO:0000313|EMBL:PJE35310.1, ECO:0000313|Proteomes:UP000231553};
RN [1] {ECO:0000313|EMBL:PJE35310.1, ECO:0000313|Proteomes:UP000231553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=157 {ECO:0000313|EMBL:PJE35310.1,
RC ECO:0000313|Proteomes:UP000231553};
RX PubMed=29219804; DOI=10.1099/ijsem.0.002521;
RA Huang M.-M., Guo L.-L., Wu Y.-H., Lai Q.-L., Shao Z.-Z., Wang C.-S., Wu M.,
RA Xu X.-W.;
RT "Pseudooceanicola lipolyticus sp. nov., a marine alphaproteobacterium,
RT reclassification of Oceanicola flagellatus as Pseudooceanicola flagellatus
RT comb. nov. and emended description of the genus Pseudooceanicola.";
RL Int. J. Syst. Evol. Microbiol. 68:409-415(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJE35310.1}.
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DR EMBL; PGTB01000100; PJE35310.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M8IXQ2; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000231553; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000231553};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..236
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 269..603
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 613..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 71038 MW; E7321E7CC6C06ECF CRC64;
MKRNPREIEQ THRKLSRRAL VVGGLQLGFV GALGMRMRYM QVDQADEFRL LAEENRVNIR
LIAPSRGELF DRNGIPLARN VPSYRLVMVR EDAGDIDTTI ANLAKLVDLD PDELNRALDE
MRRRPPFLPI TLADRVSWED ISRVAVNAPA LPGVTPEVGL TRVYPHGPDL AHVVGYVGPV
SDYDLEQIED PEPVLRIPRF QIGKVGLEAR EEDLLRGKAG AKRVEVNATG RVMRELDRRE
GQPGADLQLT VDADLQSYVQ ARLAGESASA VVIDCETGDL CAISSAPSFD PNLFVQGISV
ADYRMLTEDK YRPLANKSVQ GTYPPGSTFK MVTALAALEA GVVGPGDTVW CPGYLSISGR
RFHCWKGGGH GHMNLQDSLK QSCDVYYYDV AIKTGIDAIS SMARRLGLGV RHELPMSAVA
RGLAPDRAWK QEVHNQTWLV GDTANAAIGQ GYMLASPLQL AVMAARIATG RAVTPRLVKS
VNGVERPSGR GEPLDINENH LRQVRRGMDE VTNGRGGTAY RSRIIAEGFQ MAGKTGTSQV
RNITKAERAA GVINNRDLPW ERRDHALFVC FAPLEAPRYA VSVVVEHGGG GSTAAAPIAR
DVMLQALYKG TPPLEAYPTA DREKMREQQE KLQRERHNRQ SGASDRA
//
