ID A0A2M8LRN2_9ACTN Unreviewed; 378 AA.
AC A0A2M8LRN2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 28-JUN-2023, entry version 17.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686};
GN ORFNames=CUT44_30805 {ECO:0000313|EMBL:PJE94589.1};
OS Streptomyces carminius.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2665496 {ECO:0000313|EMBL:PJE94589.1, ECO:0000313|Proteomes:UP000230407};
RN [1] {ECO:0000313|EMBL:PJE94589.1, ECO:0000313|Proteomes:UP000230407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TRM SA0054 {ECO:0000313|EMBL:PJE94589.1,
RC ECO:0000313|Proteomes:UP000230407};
RA Wang Y., Luo X., Wan C., Zhang L.;
RT "Streptomyces carmine sp. nov., a novel actinomycete isolated from Sophora
RT alopecuroides in Xinjiang, China.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001058};
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005049}.
CC -!- SIMILARITY: Belongs to the CobT family.
CC {ECO:0000256|ARBA:ARBA00007110}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJE94589.1}.
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DR EMBL; PGGW01000069; PJE94589.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M8LRN2; -.
DR UniPathway; UPA00061; UER00516.
DR Proteomes; UP000230407; Unassembled WGS sequence.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02439; DMB-PRT_CobT; 1.
DR Gene3D; 1.10.1610.10; -; 1.
DR Gene3D; 3.40.50.10210; -; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF02277; DBI_PRT; 1.
DR SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:PJE94589.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000230407};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PJE94589.1}.
FT REGION 351..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 38651 MW; E61434B3D105681B CRC64;
MSDGSLNLDD FGDLIERPDS GVRRDAEERR ARTGLPAGAL GRLDELGEWL AAAQGRVPVE
PVSRPKVLLF AGDHDVASLG VSARPAGGAH ALVRAALEGT SPAAVLARRL GVPLRIVDMS
LDCDPDGLPE EVTRYRVRRS GGRLDIEDSL TAQEAERAFR AGMAIADEEA DAGTELVLLG
DISVGGTTAA GVLVAALCGT DASVVTGRGG GRIDDLAWMR KCAAVRDGLR RARPALGDQL
RLLATVAGAD LTAITGFLLQ SAVRRTPVVL DGVVSAACAL VAQRVAFRAP DWWLAGQASG
EPAQARALDR MALDPLLDHG VTAGEGTGAL LALPLVQAAS ALAAELPVRA AEPDGADGAG
GSGQDGGRPG AAEALDAT
//
