ID A0A2M8S4I8_9PAST Unreviewed; 646 AA.
AC A0A2M8S4I8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:PJG86066.1};
GN Name=iolD {ECO:0000313|EMBL:PJG86066.1};
GN ORFNames=CVP05_02540 {ECO:0000313|EMBL:PJG86066.1};
OS Conservatibacter flavescens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Conservatibacter.
OX NCBI_TaxID=28161 {ECO:0000313|EMBL:PJG86066.1, ECO:0000313|Proteomes:UP000229329};
RN [1] {ECO:0000313|EMBL:PJG86066.1, ECO:0000313|Proteomes:UP000229329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7_4 {ECO:0000313|EMBL:PJG86066.1,
RC ECO:0000313|Proteomes:UP000229329};
RA Christensen H.;
RT "Reclassification of Bisgaard taxon 7 as Conservatibacter flavescens gen.
RT nov., sp. nov.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJG86066.1}.
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DR EMBL; PHHA01000003; PJG86066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M8S4I8; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000229329; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd02003; TPP_IolD; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:PJG86066.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000229329};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 7..134
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..353
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 442..601
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 646 AA; 71493 MW; 5C8CB18C3C7C8505 CRC64;
MKTIRLTVAQ ALIKFLDHQY VEFDGKITKF VEGIWGIFGH GNVLGLGQAL EQDSGELILR
QGRNEQGMAH AAIGFAKQNL RKKIYACTSS VGPGAANMVT AAATATANRI PVLFLPGDTF
ATRQPDPVLQ QMEQFHDLTL STNDAFRAVS KYWDRISRPE QLMTACINAM RVLTDPADTG
AVTLCLPQDV QGEAYDYPDY FFQKRIHRIE RTPPTEAMLN QAVELIKAKK KPLLICGGGV
RYSEAAEHLK AFAQAFNIPF AETQAGKSAV ISDYDLNVGG VGETGCLSAN LLAKEADLII
GVGTRYTDFT TSSKWIFQNP DVTYLNINAA RFDAYKLDGV QVTADAKETL EKLTALLQPT
GYSAQWGNRI TEVKKLFAEE LERVYHATYT GKGFVPEVDD RLDHETVFEE FIKLTGSSMT
QSRVLGILNE TLDNNAVIVG AAGSLPGDLQ RTWQSKGENT YHLEYGYSCM GYEINAALGV
KIAQPEREVY ALLGDGSYMM LHSELVTSIQ EHKKINIVLF DNMTNGCINN LEIGHGMDSF
GTEFRFRDPK TNQLSGGFVP VDFAMNAASY GCKTYKVTTE EELYAALADA KKQTVSTLID
VKVLPKTMVH GYGSWWHVGM AEVSEKATVQ QAYEELQQRK AQARRY
//