ID A0A2M8TGB5_9CLOT Unreviewed; 2492 AA.
AC A0A2M8TGB5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:PJI10003.1};
GN ORFNames=CUB90_19955 {ECO:0000313|EMBL:PJI10003.1};
OS Clostridium sp. CT7.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2052574 {ECO:0000313|EMBL:PJI10003.1, ECO:0000313|Proteomes:UP000230839};
RN [1] {ECO:0000313|EMBL:PJI10003.1, ECO:0000313|Proteomes:UP000230839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT7 {ECO:0000313|EMBL:PJI10003.1,
RC ECO:0000313|Proteomes:UP000230839};
RA Xin F., Chen T.;
RT "The draft genome sequence of Clostridium sp. CT7, a unique bacterium
RT capable of producing butanol from glycerol uncoupled acetone and 1,3-
RT propanediol formation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJI10003.1}.
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DR EMBL; PETE01000002; PJI10003.1; -; Genomic_DNA.
DR RefSeq; WP_066022854.1; NZ_PETE01000002.1.
DR OrthoDB; 51171at2; -.
DR Proteomes; UP000230839; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000230839}.
FT DOMAIN 965..1040
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2004..2077
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2492 AA; 288027 MW; D6D6D25511149993 CRC64;
MNSINKKFEI THPQKRIWYN EILFPGTSMH NIVSKIYIGG NLDIHLLEKT INLIIKKNDS
FRLKFYEEDG KLYEYVEEYK FINVPFLDFT MYKNNAEKQL DEFCINEGRK TLYRQNELLF
KFFIYKINDE NMGICFFIHH LIFDGMSCNL LIKQFCNIYN QLCSNKVVNS NVENSYIDFI
YDENKYLSSK EFKENKQFWN EKFSNLNENS LYVNPKSTKS RIKSFTLSQN MQKGLEKFLN
DKNISLNKFF ISISSIYMSR ILNDNDITLA VACFNRDSER QKNTIGMFTG TMPLRINIKD
NITFNEFLDY LNMELKSCYH NQKYPYDLLV QDLELKRKGF DSLFKFCVNY YVLDSYNLEA
SNNMYTYNEI LAQEHANIPL HIFIKKLKRK ENIQLEIHYR IEDYTEQQIT QMLKGMEVIA
IQIINNPNMK ISQIQVVSEE EKNIILNKFN NTKREYAENK TVKELFEDIA KRFQNRTAVV
SNGEYLTYKE LNERANQLGR TLIKNGVVKE DIIPILCDRS VDTIVGMLAI IKSGAAYLPI
DEDYPEARIN YMIKDSRSKL LLIKKHQLKK INLERTSVQL IDLKSADIFK ESKENLKNIN
TPKDLVYVIY TSGSTGNPKG VCVENKNLVK LVNNPDCIEI NENDRVLQSG SLSFDASVFQ
IWIALLNGAA LHLENKLLTI SDIELENYIS HNKITVMLMP TPLFNQYCDI NIGIFKNLKY
LMAGGDVLSS KKVSRIKKTY KNLKIMNIYG PTENTVVSTA YEVKEDWDEN RSVPIGVPIS
NSTAYIMDKN NNLLPIGVAG ELCVGGDGIS RGYLNRKDLT KEKFIENPYV KGEKIYKTGD
FAKWLPDGNI HFIGRMDYQV KINGFRIELQ EIEAKLLKYS KLKEAVVAAQ KDKDGNKYLC
AYVVSKEKVS SKEIRDFLKK EIPGHMIPSH IMQLESMPVN SNGKVDRKAL PIPDLSAQSD
AEFIEPRNEM EQKLENIWCK VLNIKKVSVK DNFFELGGNS LTAIRLVSKI HKELKYKIVV
TDIFNKPSIE ELAEYLKGNI SDGIAGFKQI KKANKADYYE ASPVQKRLYA VNQTNVNSTN
YNIPLVYVIK GNFDRYRFEK SICKLINRHE ALRTSFHVID GDIFQKIHAV ADFKTKYIYA
GMKFDKNKFQ AKKFIKPFDL SKSPLIRAFI IEFLDAFVLI IDMHHIISDG VSVGIIMKEL
SELYNEEKLN ELRIQYKDYS NWVNNMYEKN LLKEQENYWL NEFKGKPFEM NVCLNGKKVL
NKDFKGNTIK FKIDKKLTSK INKTLNNLGI TKFMFYISAY YVLLYKYTGQ EDLIIGTPVS
GRTNEDIKDT VGMFVNMLPL RSNISGNMSF KEVLSEVKSN SLNAFENQEY DLKNLIEKLN
INDTSLFNIT FSFQNLNIDN LSFKDTEISM YNLKSETAKF DVSMILKENK EYTFGELEYK
KSVYSKKFME NFANHYINIL SEVTKDFSCS ISEIDILSKR EKSIILNNFN NTKREYAENI
TIKELFEEIA ERFKDKTALV SNGERLTYKE LNERANQLGN ILVKKGVVKE DIIPILCDRS
VDTIIAMLAI IKSGAAYLPI DEEYPETRIN YMIKDSRSKL LLIKKHQLEK INLEKINVQL
IDLKSEEIFK GSKENLENIN TPRDLVYVIY TSGSTGNPKG VCVENRNLVK LVNNPDYIEI
KENDKVLQCG SLSFDTSVFQ IWVALLNGAA LHLENKVLTI SDIELENYIN HNKITIMVMP
TPLFNQYCDN NVEIFKNLRY LMVGGDVLSS KKVSKIKRIY KNLKLVNGYG PTENTVISTV
YEIKEDWDEN KVVPIGVPIS NSTAYIMDKN NNLLPIGVPG ELCVGGDGIS RGYLNREDLT
KEKFIENPYV KGEKIYKTGD FAKWLPDGNI YFMGRIDYQV KINGFRIELQ EIENNLLRIE
GINAAVVLEK CENENNYLCA YYLGEKEYSV GELRKELKNF LPEYMLPSYF VKLDSMPLTP
NGKVDRKALP NPEEKINMGV EYEPPRNKIE KNIMETWQDV LGLSTIGIND DFFEIGGNSL
KAISVVSKLS REFSIVINDI FEYPTIRELA LNIKSKFYVA AKGEIAATTG FENEIPHEIK
VEYDRYIHDI EKYKKVNLNK EVSYKNILLT GATGYVGVNI LKEIMINTDS KVHLLLRGKS
IEAAEERIMQ KTDFYFGQEF YHKYRHRINI LCGDISKDKL GLNVEIYKKY LSEIDCIINS
AANVKHYGKY EDFYDINVLG TKRLLDFAMA GLKKDFNQIS TMSVASGSIP NNKLVMFSES
DIDIGQKSNN VYVRSKLEAE KLVKKASENS LNIKIFRLGN VMFNYGTGLF QENIKENAFY
KNIKAFVRLK CVPNIKGDIF DFSYVDQLSK AIILIFNKCD LKNQVFHIIN PKKISTSNLV
TLLNTKYKNI KLKDMNEFLS CISLKGESDE LREYVDNIKV NFGLLDDNSS TRFITVNERT
NAILNKLDFE WSKLDEDAIK RMLNYCEKVK FL
//
