ID A0A2M8W6J6_9MICO Unreviewed; 908 AA.
AC A0A2M8W6J6;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=CLV34_2459 {ECO:0000313|EMBL:PJI86543.1};
OS Luteimicrobium subarcticum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Luteimicrobium.
OX NCBI_TaxID=620910 {ECO:0000313|EMBL:PJI86543.1, ECO:0000313|Proteomes:UP000231586};
RN [1] {ECO:0000313|EMBL:PJI86543.1, ECO:0000313|Proteomes:UP000231586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22413 {ECO:0000313|EMBL:PJI86543.1,
RC ECO:0000313|Proteomes:UP000231586};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJI86543.1}.
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DR EMBL; PGTZ01000010; PJI86543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M8W6J6; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000231586; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 4: Predicted;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Reference proteome {ECO:0000313|Proteomes:UP000231586};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 36..181
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 409..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..468
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 91843 MW; 6F3B3F70B661D956 CRC64;
MSTALYRRYR PDTFADVIGQ EHVTGPLMQA LRTGRVNHAY LFSGPRGCGK TTSARILART
LNCHRNTPEH PVDTPCGECP SCVDLARGGP GSLDVVEIDA ASHGGVDDAR ELRERATFAP
TRDRFKVFIL DEAHMVTPQG FNALLKIVEE PPEHIRFIFA TTEPDKVIGT IRSRTHHYPF
RLVPQDVLQP YLEQLCATED VEVGGGVLPL VIRAGGGSVR DTLSVLDQLI AGADETPSPE
GADDSAGAAG PRGRVLGYEQ AVDLLGYTHA NLLDDVVDAL AAHDGASLFR VVERVVASGH
EPRRFVEDVL ERLRDLVVLA VSDGDAGAVL AGLPAEQVER MRAQATALGL GELSRAADLA
NAALTEMTGA TSPRLHLELL CARLLLPGAD DGAAGFGARL DRLERGWQAS GGPASAAPAA
PAAPSPTASP AAASTVASDD VLGARPPRRE PSVRLAPVPT PAPEPAVATP EASPGDEVSS
AADPSDAADP APAAPAEAAP APESPAAPAP PAAGRGAASV AHVESEVVRR RWDEVLSTLS
RLSRAAWSLV HQNATVAGLD GNVLTLSFQS AGLQRALQGP KVEAVEQAVY ETLGFPVKVT
AVVGGAAPAA TGAPRARENR APATTVEAPT DDAPGDRGPA SAGSRTSPPA GATVSPSVPS
LPSPPAVASA GSDPAAGVAA AASSWGDVVV ALPGGASSVR PAPSVRPAPS VDGPAADAPR
DADRTTDRPT PAASISGSDA PAAATQPAGS PVDPAPSDGA SAVGVASGPD DDLPPLAEPP
HDVDDLPPWE DGAAPSVPTP SVPATPAPAT SAHAVSTREP TGQAPTVPGP ARPAPAGAGS
TASVSTSPAG SGRPAPAVRG GGQGSSRPAP YGRPGQQRAP IPPDLVGPPL VAHMLGGVIL
EEIVDNPD
//
