ID A0A2M8WR68_9MICO Unreviewed; 565 AA.
AC A0A2M8WR68;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=DNA polymerase-1 {ECO:0000313|EMBL:PJI93432.1};
GN ORFNames=CLV34_2005 {ECO:0000313|EMBL:PJI93432.1};
OS Luteimicrobium subarcticum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Luteimicrobium.
OX NCBI_TaxID=620910 {ECO:0000313|EMBL:PJI93432.1, ECO:0000313|Proteomes:UP000231586};
RN [1] {ECO:0000313|EMBL:PJI93432.1, ECO:0000313|Proteomes:UP000231586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22413 {ECO:0000313|EMBL:PJI93432.1,
RC ECO:0000313|Proteomes:UP000231586};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJI93432.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PGTZ01000008; PJI93432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M8WR68; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000231586; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000231586}.
FT DOMAIN 304..522
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 565 AA; 59483 MW; E173EF090B4D9CB4 CRC64;
MHVVVAEPAV SPDGADAAAV VGLTGDPAAT EPPRWTWADT NLWYPGLLAA GARVARAHDL
RLAHRVLRTS AWTTGTALAT RGAGPWDALP TLPVTGRDTG PSDQHALFEI GPDGTAGADD
RSPDAPACRA ALRDQLAAVA ASTRPGRLRL LLAAEAAGAL AAVEMHHVGV PWDAVVHDAV
LTESLGARPP AGTAPPRMAA LADDVRTALD APNLHLDSMP DVLRALRRTG LPVTSTRSWE
LREVDHPAID PLLAYKKLSR LHSANGWSWL EQWVHGHRFR PEYVVSGVVT GRWGSSGGGA
LQLPRRLRTA VRADPGWVLV VADAAQLEPR VLAGLARDER MAAAGHGQDL YQGMVDAHVV
DSRAHGKVGM LGAMYGGTTG ASAAVLPRLA KAFPASLALV EAAARTGEVG GVVTTHLGRT
SPRPGAAWHD TQALAQTEDA GVDDESRARA QTRAWGRFTR NFVVQGTAAE WALCWIAGVR
RDLWALGEQP GPASRAPEPF ARRPHLAYFL HDELVVHCPA ALADDVARLV QDAAAGAGQL
LFPGFPVDFP LSVGAATSYA DAKDA
//
