ID A0A2M9A7R1_9BACT Unreviewed; 1271 AA.
AC A0A2M9A7R1;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BGX16_1743 {ECO:0000313|EMBL:PJJ41749.1};
OS Hallerella succinigenes.
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Hallerella.
OX NCBI_TaxID=1896222 {ECO:0000313|EMBL:PJJ41749.1, ECO:0000313|Proteomes:UP000231134};
RN [1] {ECO:0000313|EMBL:PJJ41749.1, ECO:0000313|Proteomes:UP000231134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWS3 {ECO:0000313|EMBL:PJJ41749.1,
RC ECO:0000313|Proteomes:UP000231134};
RA Neumann A.;
RT "Animal gut microbial communities from fecal samples from Wisconsin, USA.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJJ41749.1}.
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DR EMBL; PGEX01000001; PJJ41749.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9A7R1; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000231134; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000231134};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..81
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1271 AA; 143789 MW; 5D8FA3842BF41C56 CRC64;
MSFVHLQLHS EFSILQAAAR LDDIFDAAAA DNAPAVALTD HGTMFGILEF QERGKALNKK
RKEKGLPPIK TVLGCHIYVD TPGANFKEPG GYERLTLLVE NEQGYYNLLR IVSYRYEESK
RWEQIPSVPL EIVEEHKEGI IAIAGDYASR YGINVTAGRD AQAKTYIETL DKIFDHDHLY
LSICDNGISA QKTLNLFTVA LAKELNRELV AVGDVHYIKR EDADAHKALR CISLVEKFKE
FNDKRFPTNQ FYYRAEAEMR ELFPDHPEAI DNTVKIADRC VFEVKTGIGD DFWPRYEIPK
EFLESEECKE IYRVMEDEYN KGYPEAFEKA AKEFCKKNKD KTIETLTDED KDAVEKIMEH
NKTSRHGGDA DAYLIHLTRE RLHWRFPNEN TQYPSHDSEV SDRIYKELNC IRNMNVAGYL
LIVWDFINWS REHGIPVGPG RGSAAGSIVT YIIGITNIDP LKFGLLFERF LNPERVSMPD
IDTDIADRDR GRVIDYVTRK YGADCVGQII TYGMLKSKAV IKDVARVLSI DHREADAIIK
LFPQRVLNFS LNDAWTGKTK KGAPVAPDYD PAPLQAFINS RESYKELWDI AKRLEDLPRQ
TGVHACGVVI TPTPIYNLAP LYRAAPLDTP VVMYDKHYSE TIGLLKMDFL GLINLSIIQD
TVNLAKKTRG VDIDMDKVPT DDKETFELLS KGMTTAVFQF ESPGMQKYLR ELKPSRISDL
IAMNALYRPG PIDQIPHFIA RKLGKEEIDC YHKDLEQVLG ETYGVIVYQE QVMQLAQILG
GYSLGGADNI RRIMAKKMPE KMAKLEPEFF QKCLDNGYDK AMIQKVWNAV LPFCGYAFNK
SHAAAYAYVA YQTAYLKTHF GPEYMAASMT SKMGKTEDIV TIVQECRRMN IEVLPPDINS
SLGVFSANAE GKVVYGLAGI RNVGLPVIED VVAEREAHGP YTTLFDLCKR VADYQAAQPE
KRPPLNRKTL ESLIMAGAFD KMSPTVPNRP TLLASVEKAL EVANRHRKEQ DAGQTSLFDM
FGGAALEEAH MDETYEDAQP WGLMELLNKE RDVLGLYLSA HPLDECRPEL RGFTTNSLAE
SELNEIVEAN PKSIVCVGGI ITKLRSFQSK KDETKTMGSG TLQDFQGEIA IFFPPDSWER
CRDHFGEDDR VIVKGKLCPQ NQDPSALQII VDKAFSIDEV RTRLVNFIHV NVSSMELVDE
KMTQILERMD MAQALPGEHA AEMVFHVETV SGHIHTLRAQ VAKIAYTPDF FEWLQTEFGP
SNVWVSAKVK A
//
