ID A0A2M9B963_9BACT Unreviewed; 906 AA.
AC A0A2M9B963;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=CLV45_2827 {ECO:0000313|EMBL:PJJ54489.1};
OS Hymenobacter chitinivorans DSM 11115.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1121954 {ECO:0000313|EMBL:PJJ54489.1, ECO:0000313|Proteomes:UP000228535};
RN [1] {ECO:0000313|EMBL:PJJ54489.1, ECO:0000313|Proteomes:UP000228535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11115 {ECO:0000313|EMBL:PJJ54489.1,
RC ECO:0000313|Proteomes:UP000228535};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJJ54489.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PGFA01000002; PJJ54489.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9B963; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000228535; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 696..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 622..629
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 906 AA; 100771 MW; 09A4A95DEB90704D CRC64;
MHGTLGPAPV IDTPLMKQYY QLKEQHPGAL LLFRVGDFYE TFGEDAVTAS RILDITLTKR
GAGTSSETPL AGFPHHALDN YLPKLVRAGQ RVAICDQLED PKQAKGLVKR GITELVTPGV
SFNDNVLERR SNNYLAAVHF GKQECGIAFL DISTGEFLVA QGDHAYLGKL LQNFSPAEVL
FCKKSRSEFE QHYGPDYCHY ALDEWVFGAD YTYETLTRHF NTASLKGFGI DGLREGITAA
GCIMHYLAET KHTDIGHIAS IGRLEEDKYV WLDRFTVRNL ELVHAQHPGG VPLIDILDQT
VTPMGARLLR KWVVLPLKEP AQIQRRLDTV EGLLDNPELL GELVQHLKQI NDLERLISKV
AVRRINPREL LQLSRALDAI GPIRELLAGS GMRALQKLAD QLNACETLRE EIKAKIRPDA
PILTNQGNVL NEGIDPELDE LRSIAFSGKD YLFQLQQREI QNTGISSLKV AYNKVFGYYL
EVTNAHKDKV PATWIRKQTL VNAERYITEE LKTYEEKILH AEERLFVIEQ NIYNELVLSA
MDFVPQIQQN ARAIGIIDCL ASFAATARQQ RYVKPVVNDS TLLDIRAGRH PVIERQLPPG
EAYIPNDIRL DQEEQQIVVI TGPNMAGKSA LLRQTALIVL LAQIGSFVPA DAATIGVIDK
IFTRVGASDN LSKGESTFMV EMTETASILN NLSDRSLVLM DEIGRGTSTY DGISIAWAIV
EHLHNNPRAR AKTLFATHYH ELNQLAEDCP RVRNYNVAVR EADGRILFMR KLVEGGSEHS
FGIHVARMAG MPTAVVLRAN EIMHHLEQER ASTGLEEGPT EFDEVLAGLE AEPKNGKASR
GPVAQPAAAV ASAPRPSLQL SMFEPADPVL ERIREQLQQL DVNTLTPIDA LLKLNELKLA
LGAKSK
//
