ID A0A2M9CMA8_9MICO Unreviewed; 289 AA.
AC A0A2M9CMA8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase/2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:PJJ73025.1};
GN ORFNames=CLV46_2605 {ECO:0000313|EMBL:PJJ73025.1};
OS Diaminobutyricimonas aerilata.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Diaminobutyricimonas.
OX NCBI_TaxID=1162967 {ECO:0000313|EMBL:PJJ73025.1, ECO:0000313|Proteomes:UP000228758};
RN [1] {ECO:0000313|EMBL:PJJ73025.1, ECO:0000313|Proteomes:UP000228758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27393 {ECO:0000313|EMBL:PJJ73025.1,
RC ECO:0000313|Proteomes:UP000228758};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJJ73025.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PGFF01000001; PJJ73025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9CMA8; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000228758; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF80; BLR4309 PROTEIN; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000228758}.
FT DOMAIN 8..157
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 160..265
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT REGION 270..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 166
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 289 AA; 29820 MW; DE027B16DB9335D9 CRC64;
MTSSSAVIVG LGNLGSPLAS RLLEVGWDVA VLDTAEERVA ELRGEGAREI DVADLGREPL
VCFVVPGEQA IRSVLERVEG PLEGLVVVIS TLAPQTAIDV AATLAERGAR MIDAPVSGGA
DRARAGELTV LVGGADEHVA DARPLLDAIG DTVLHVGPVG AGSAAKLANQ LVTFASLGAV
LEAARLADAY GVAESTVIEA LGTATGDTWV GRTWGFYDDL AADYDRRDVP DDDRPWVKDL
AAVRAAASGA GLEVPVADVL SRTLADDIRT HAQRSRQTDS EGAQEGADA
//
