ID A0A2M9EA98_9GAMM Unreviewed; 604 AA.
AC A0A2M9EA98;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=CO641_03715 {ECO:0000313|EMBL:PJK01047.1};
OS Xanthomonadaceae bacterium NML91-0213.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae.
OX NCBI_TaxID=2032582 {ECO:0000313|EMBL:PJK01047.1, ECO:0000313|Proteomes:UP000229012};
RN [1] {ECO:0000313|EMBL:PJK01047.1, ECO:0000313|Proteomes:UP000229012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML91-0213 {ECO:0000313|EMBL:PJK01047.1,
RC ECO:0000313|Proteomes:UP000229012};
RA Bernier A.-M., Bernard K.;
RT "Zoonotically transmitted species of Xanthomonadaceae : Genome sequencing
RT and assembly.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJK01047.1}.
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DR EMBL; NWQL01000001; PJK01047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9EA98; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000229012; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:PJK01047.1};
KW Hydrolase {ECO:0000313|EMBL:PJK01047.1};
KW Nuclease {ECO:0000313|EMBL:PJK01047.1}.
FT DOMAIN 210..328
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 417..560
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 604 AA; 65426 MW; A0FD39D5959FCDD0 CRC64;
MRIRQLPETL ANQIAAGEVV ERPASVVKEL VENALDAGAG RVDIELEEGG VRLIRVRDDG
GGIPPDDLPL AVSRHATSKI ASLDDLEAVA TLGFRGEALP SIASVSRFLL VSRTADAAHA
SALAVEGGQV GDLEPKSHPT GTTVEVRDLF YNVPARRKFL RAERTELGHV EDWLRSLALA
RPDVELRISH NGKPLRRYRG GGSLFEDGRL EETLGAEFAR QALRIDHSAA GLRLSGWIAR
PAYSRASADQ QHLYVNGRAV RDRSISHAVK QAYADVMYHG RQPAYVLFLE LDPTRVDVNV
HPAKHEVRFR DGRLLHEFVY RTLQGALADT RAGLGAAVAS EASSLQPLPA SAFSASWAGP
VEPREQSNLA LRVDELRAGY AALYGAAAPG VLAGGAAGAS PAMPDADDQG IPPLGFALAQ
LHGIYILSQA ADGLVVVDMH AAHERIGYEK LKAAHDSEGL RMQPLLVPQT VAVAEREADI
AQREAAVLAD LGFDVSRAGP QSLLLRGVPA LLAQGDTEAL LRDVLADLRE HGHSRRVRSA
RDELLSTMAC HGSVRANRRL TVPEMNALLR QMEETERSGQ CNHGRPTWTR FGLAEIDRWF
MRGR
//
