ID A0A2M9ECJ1_9GAMM Unreviewed; 846 AA.
AC A0A2M9ECJ1;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:PJK01999.1};
GN ORFNames=CO611_01985 {ECO:0000313|EMBL:PJK01999.1};
OS Xanthomonadaceae bacterium NML03-0222.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae.
OX NCBI_TaxID=2032581 {ECO:0000313|EMBL:PJK01999.1, ECO:0000313|Proteomes:UP000229850};
RN [1] {ECO:0000313|EMBL:PJK01999.1, ECO:0000313|Proteomes:UP000229850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML03-0222 {ECO:0000313|EMBL:PJK01999.1,
RC ECO:0000313|Proteomes:UP000229850};
RA Bernier A.-M., Bernard K.;
RT "Zoonotically transmitted species of Xanthomonadaceae : Genome sequencing
RT and assembly.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJK01999.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NWQM01000001; PJK01999.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9ECJ1; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000229850; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000229850}.
FT DOMAIN 677..693
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 603..610
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 846 AA; 92970 MW; DD20642C05523B17 CRC64;
MRQFLAAKAE HPDVLLFFRM GDFYELFYDD ARKAARLLDL TLTQRGMSAG QPIPMAGVPH
HAYESYLARL VALGESVAIC EQIGDPATSK GLVERKVVRI VTPGTVTDEA LLQDRRDTLL
MAVARGKEGY GLAWADLAGG RFHVAQLGND DMLEAELARL EPVELLIADE EGWPEALLSR
SGVRRRAPWL FDADAARRKL LAFFGLHDLS AFGIDALPLP VAAAGALLGY VEETQKQRLP
HLTAITLESG DGAIAMNAAT RRHLELDTRI DGDSRNTLLG VLDSTITPMG GRLLRRWLHR
PLRSQNIINA RLQAVQTLLD ARVTEDLRTT FRGFGDIERI LTRVALRSAR PRDLSTLRDA
LANLPALRAD FEGLDSPRLA ELAGRMGEHA EIADFLQRAV VAQPPLLARD GGVIAEGFDA
ELDELRRLST HADQFLVELE AREREATGVA TLKVGYNRVH GYYIEMGKVH ADKAPVHYSR
RQTLANAERY ITEELKNFED KVLSARERAL TREKFLYEAI LDRLNDNIAP LRACAEALAE
LDVLCAFAER AEALDWARPA LVEQPGLEIR DGRHPVVEAV RQEPFTPNDL HLDADSRMLI
ITGPNMGGKS TYMRQNALIV LLAHIGSFVP ARSARIGPID RILTRIGAGD DLAKGQSTFM
VEMSETSYIL HHATSQSLVL MDEIGRGTST YDGLALADAC ARHLADDNRS LTLFATHYFE
LTALAKPGSG IRNVHLDAVE HEDRLVFMHA VKEGPANRSF GLQVASLAGL PKTVVSAARA
RLAELEQDGQ AKPAKPLSAA TPAQPQQIGL FAPTRSAAEE ALAALDPDEL TPKQALEAIY
RLKALR
//
