ID A0A2M9HPJ4_9BIFI Unreviewed; 1302 AA.
AC A0A2M9HPJ4;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CUU80_08155 {ECO:0000313|EMBL:PJM78699.1};
OS Bifidobacterium scaligerum.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=2052656 {ECO:0000313|EMBL:PJM78699.1, ECO:0000313|Proteomes:UP000228755};
RN [1] {ECO:0000313|EMBL:PJM78699.1, ECO:0000313|Proteomes:UP000228755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TRED {ECO:0000313|Proteomes:UP000228755};
RA Mattarelli P., Modesto M., Bonetti A., Puglisi E., Morelli L.;
RT "Draft genome sequences of strains TRE 1, TRE D, TRE H and TRI 7, isolated
RT from tamarins, belonging to four potential novel Bifidobacterium species.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJM78699.1}.
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DR EMBL; PGLQ01000005; PJM78699.1; -; Genomic_DNA.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000228755; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000228755}.
FT DOMAIN 5..380
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 381..731
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1302 AA; 142579 MW; AF3588A4EC71B6B6 CRC64;
MSTFVPSPEQ ASIINAPADS DVLVVAGAGS GKTFTMTQRI IALIHRGVAP ERILGLTFTR
KAAGELLERV SSAVAGETDS ADASAIISDR AFLKPAIFTY DAFFQTIVRQ YGLLVGFDQQ
TQPLSQAGAL QLATEVIDAH MDLVFQEDFG SFSHLAGYVL TLSDAIGSAM IGGDCVSFAQ
AVDLVRQWDT AFAKRIETVL EHETVPDAEP TIPKIKRLKK DTDASWQAKL DDRAAALHAR
CAYHCGELLQ TVRKRDILLQ LVEAYAQAKR ERNMAEFSDF TIAAFQLISR FPSIGKRIRR
RYTHVLLDEY QDTSTTQAAL LASLFHTKDG RSAVNAVGDP FQSIYAWRGA SPGAFRMFQR
DFHMDPDSKP FPLSVTRRNS RIVLEAANDL TLPLRSHPAR PSSSLMREVG VSSLDPMPNA
PEGTLGVLGF ATAGQEMDAV VRFCKQAISQ YRARDGKEAD DGGKASVAVL FRSKSRMPQY
QEALEQAGLT TFVVGYSALL ERPEIRDLMA LLHVASDHTD SGSLMRLLAT PRFAVSADDL
TLLARVAEQC NTEQRFRALV QAGLASADAP QEQWATVVRE HRDQVANAVF LPDVLLRTDI
ELLIKPLSEW GRSAVSHMAK ALRHVHGAIG RPLNDVIRVG VEALDLDIDT VVAEALHDPR
RHANPTVARM PMHAIVDLVD TYTREIAIDQ TPTLRGFMAW VDQLSSVEDE AANLPDTSVD
VELMTVHQSK GLEWDAVAVV GLTAGGFPSN QGDHLKVELD ERHPGGLEHG RWVAPQYRDV
ADSWLTDPTA VPVPVRADAA ILPRFPHDAD VAMSPMEALE TLDDVELIDD EAFGSMRQFG
DGVDEVDASG WYLTQTEEYG RRLHADERRL MYVALTRARS DAMLTYSAYA GEYGRDPSAV
PKGARAAQAS NFWLEVHDAL ISHDHVVTAR QCVEQLGDKV ALVSKQDEPI EAPEGFFIGE
RASVYCNAVI GAAWSTPIAQ QDKAESLPWP ATLSASIVER LDRGIGAVRQ QIEQADRIAA
GHIAAGKGAA AIGGHVQESQ GELECHQPAG PLLQRAQILV SDGDLMTGPL QGQALDEMVK
AKAQRVLSAG RQNVTGLQAR VGGMGEREER MYWRSIVRPV PRISSPAAEA GTRFHEWAQR
FIGAGSIDER GTREAVAMDE GELLQWQKRL AASRWARRTP VWLERAIVVD VPGIGIVNGK
LDAVFAGGLD PRDSSKRFTI VDWKTGQRPT QPQDVARKLA QLDMYRLLLA VVEGAALESI
DATLYYVSES QEDLRELKAR AKTKQEILTE LSSGISEQSD ND
//
