ID   A0A2M9HS45_9BIFI        Unreviewed;      1044 AA.
AC   A0A2M9HS45;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:PJM79622.1};
GN   ORFNames=CUU80_00220 {ECO:0000313|EMBL:PJM79622.1};
OS   Bifidobacterium scaligerum.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=2052656 {ECO:0000313|EMBL:PJM79622.1, ECO:0000313|Proteomes:UP000228755};
RN   [1] {ECO:0000313|EMBL:PJM79622.1, ECO:0000313|Proteomes:UP000228755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TRED {ECO:0000313|Proteomes:UP000228755};
RA   Mattarelli P., Modesto M., Bonetti A., Puglisi E., Morelli L.;
RT   "Draft genome sequences of strains TRE 1, TRE D, TRE H and TRI 7, isolated
RT   from tamarins, belonging to four potential novel Bifidobacterium species.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJM79622.1}.
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DR   EMBL; PGLQ01000001; PJM79622.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9HS45; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000228755; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000228755}.
FT   DOMAIN          537..616
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1044 AA;  116265 MW;  A86EF971E7F4A95D CRC64;
     MFLKPEQQLE RCKRVLRQRV NPHIHPVIEH LKVEAFDIPG EPMPSGEFFD KVGRGEITFH
     PFTLGNEWGT TWGTVWFRLS GVVPAGYPQG RPLELMIDLG WYPHSCGGHI EGLVYREDGT
     AIKAVHPLNH WVPFMDADGN AQVPIAEDGS FTVYLEAACN PLLLGVPPFI VTELGEKATG
     KPDEPYVFKS ADLTEFDQRF ENYSVDLDVV SQLMEAADKQ SPRYWQLAKA LQRSINVFDE
     QRLDSVVAAR EQLAGVLAKP ANASAMNVSA IGHAHIDSAW LWPVRETRRK VARTVSNALA
     LMDADPDFKY AMSSAQQYAW LEEDHPDIFA RMKQRIAEGR FIPVGGMWVE SDGMLPTGES
     LIRQISYGRR YFKEHLGVEP KGIWLPDSFG YTGAWPQIAR RAGYEWFLTQ KISWNDTTKF
     PYHSFMWEGI DGSRIFTHFP PSDTYAAWCK VQELDYAEKN FQNKDLADRS ILLFGFGDGG
     GGPTRDMMEH LHRYENLEGV SRVNIETPNE FFDKAHRQIE ENAGPEMPVY KGELYLELHR
     GTLTSQQDMK RGCRTEESLL RTVEYLGAAA SIADPNFVYP SEEMDRIWKT LLLNQFHDIL
     PGSGIAWVHR EAREDYRRDI QRLQEIAEQI CAVLRASHPD RDLLPSARIS QYRADGGSWQ
     VRSICSQGET LPARVENLDD GRIRISNGAL STVIESDGGI SSLIDESRGR ELVPAGTRLG
     RYELMKDEPA VWDAWEIERE SLLMAEGLDG EIVEASIDER GSAVVVTRTI VGQTVINTTI
     TLRPGAKQLD FHTSVDWRAK ERFLKVDVPL TVTADRAVYD CQYGLVERPI VKNSASDEAK
     FESSTNRFAI LREAGYAAAV VNGSIYGSDA LQLPVDAARG LGGGTMFRLS LVSAPTFPDP
     RTDAGQHDYD WSVVADATVE RAVDAACELN APVLHDVPAV EPLVGLDVTD GTAVIDWVKL
     ADDGSGDLVV RVYEAAGGRA EASVHVCDAL RNATIRETNV LEGDAIAADL PVALVSDGID
     SEQPAEGARL HLGPFQLATL RIRR
//