ID   A0A2M9IUW2_9ACTN        Unreviewed;       740 AA.
AC   A0A2M9IUW2;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Transporter {ECO:0000313|EMBL:PJM98427.1};
GN   ORFNames=CG740_35665 {ECO:0000313|EMBL:PJM98427.1};
OS   Streptomyces sp. CB01201.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJM98427.1, ECO:0000313|Proteomes:UP000231916};
RN   [1] {ECO:0000313|Proteomes:UP000231916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJM98427.1}.
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DR   EMBL; NNBJ01000026; PJM98427.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9IUW2; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000231916; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        186..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        572..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        612..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        644..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        677..701
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          74..378
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          414..716
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   740 AA;  75821 MW;  8B993FC72F85C068 CRC64;
     MTNGSAVESG TGLLHRLGSW CARHAWRIVI GWLVLLVAIG AAHARWGGSF ADSFSLPGTS
     TQTGADLLKA HGGTSGTTAP VVIKSEQGSV ADHQAAVEAA VNNLAHLPDV VSVKDPLTTP
     GAVSPQGNIA QIGVTFTSNP AGFDHAYVGK VDTAVQPLRA DHVTVDYGDP LGQLAAPKAA
     DLTSEVIGLG VALLVLLIGF GSVAAAVLPL VTAVLGLAVG LAGLGLLAAQ FSFGQAAPTL
     AAMMGLGVGI DYALFLSTRY RALLGADGGG GIGNGLDPAE AAGRTVATSG RSVLVAAATV
     AMALAGLYVS GMGFIGTLGA AAGLTVIVAA AASVTLTPAL LGLLGRRIDR LHVRRPVAEP
     TGTDDVWHRW AARVGRSPWL FLAAGLIVLG VLAIPVGSLH LGHIDAGAQP TSTTDRRAYD
     LISQGFGPGA NGPITVVTKL DGQQAADPSK SQALATTLQH DLTAVPGVAS VTPPQPTPDH
     ALLVSTVTPD TGPQDRATTD LIHTLQDHTV PDALSGTGAT GYVTGPTVSG QTFTDTLVAK
     LPLIIGVVVA AAFVLLLCVF RSPLVALKAA VLNLFSIAAA YGVVVAVFQW GWGGSLLGVG
     EKVPIESYVP MMMFAIIFGL SMDYEVFLLA RIRETWLHGG NNHLSVATGL AATARVITCA
     ALIMTSVFLA FMLSPNVVVK MLALGLGVSV IVDATVVRLL LVPATMYLFG RANWWIPAWL
     DRRLPRLDPE GPAQHPNPDA
//