ID   A0A2M9IZQ4_9ACTN        Unreviewed;      1324 AA.
AC   A0A2M9IZQ4;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Type VII secretion protein EccC {ECO:0000313|EMBL:PJN00073.1};
GN   ORFNames=CG740_27790 {ECO:0000313|EMBL:PJN00073.1};
OS   Streptomyces sp. CB01201.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJN00073.1, ECO:0000313|Proteomes:UP000231916};
RN   [1] {ECO:0000313|Proteomes:UP000231916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJN00073.1}.
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DR   EMBL; NNBJ01000014; PJN00073.1; -; Genomic_DNA.
DR   OrthoDB; 9807790at2; -.
DR   Proteomes; UP000231916; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR023836; EccCa-like_Actinobacteria.
DR   InterPro; IPR023837; EccCb-like_Actinobacteria.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03924; T7SS_EccC_a; 1.
DR   NCBIfam; TIGR03925; T7SS_EccC_b; 1.
DR   PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR   PANTHER; PTHR22683:SF1; TYPE VII SECRETION SYSTEM PROTEIN ESSC; 1.
DR   Pfam; PF01580; FtsK_SpoIIIE; 2.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   PROSITE; PS50901; FTSK; 3.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          451..651
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   DOMAIN          816..1009
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   DOMAIN          1105..1288
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   BINDING         474..481
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT   BINDING         834..841
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT   BINDING         1122..1129
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   1324 AA;  142469 MW;  99EEF2D562797020 CRC64;
     MSHIVVKRPP RALPCGVPTE EVVLQSPPEL PRGQQEGTLM QLLPMLGMGG SVVFFFMPNS
     QPFMKIMGMV MVASTVAMSV AMIVRYRRGS QGQLADMRRD YLRHLGQARR QAAEAARRQR
     DAQYYLHPSP EQLWALVAEG SRVWERRSGD EDFGQVRVGL GPQALATALV PPQTAPVDRL
     EPLTAGAMQR FVAAHQTVQD LPMAVSLRAF YHLTLSGEAQ TVRASARALT SSLAALHSPE
     DLVIAVAASA SAAGHWEWTK WLPHTQAPGL VDGAGSRRLF SRSAAELEEL LTPRLTGRPR
     FHPEGAPLPE EPHIVVVLDG VSPPPMSQLA AAEGVQGVTV VEVVPGELTG ARGDLAMVVQ
     PRGLRLESGH GLVYEGTPDL LSYEGADALA RQLAPLRMAS GGDDDEPLLA NLEFTDLLNL
     GDADSVDTAR TWRPRSASER LRVPIGVGED GRPVMLDLKE AAQDGMGPHG LCVGATGSGK
     SELLRTLVLG LAVTHSSETL NFVLADFKGG ATFAGMAQMP HVAAVITNLA DDLTLVDRMG
     DSIRGELNRR QEMLREAGHY ANIHDYEGAR LAGAPLQPVP SLVLVIDEFS ELLTAKPEFI
     EMFVQIGRIG RSLGVHLLLA SQRLEEGRLR GLETYLSYRI GLRTFSAAES RAALGVPDAY
     HLPSVPGSGC LKFGTDEMTR FKAAYVSGAY RTGADRSAAL GGPVPVDRRP VLFTAAEVPV
     AYAPQSVPGP RPRSGPRTDD ALADTVLDVI VRRLEARGPA AHQVWLPPLD SPPALDTLLP
     GLAPVAGRGL TKPGCEGAGR LVVPLGLVDK PYEQRRDPLW CDFSGAAGHL QILGGPQSGK
     STLLRTLLAS FALTHTPHEV QFYGLDFGGG GLAAVAGLPH VGGVASRLDP ERVRRTVAEV
     YGVLTRREEY FRSAGIASIA DFRARRARGS IPVADQPWGD VFLVIDGWGN FRTEYEGLEQ
     VVLDIAARGL GYGIHLVLTA SRSMEVRANL KDHLANRLEL RLGDTMDSEF DRKVAANVPV
     GVPGRGQSPQ KLHFMAAVPR IDGLPSDTGL AEATAALATE VARHWTVPGA PAVRLLPREL
     PAAQLPPGHA APERGIAFAL DENNLEPVFV DFEQDPFFLV FGEGESGKSN LLRLLITQLT
     RRYGGEVCKL FVVDNRRALL DATPPSHLAE YIPMSNAMDH HMDALADLMR RRAPGADVTA
     QQLRDRSWWR GPTVYVVVDD YDLVSTPSGN PLGKLTELLP FARDVGVRFI IARSTAGAGR
     AAYEPFIQRM KELGAQGVVL AGDPAEGDLL AGVRPRPMPT GRGTFVSRRR GKPLVQTGLV
     EGAN
//